Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | CES2 | O00748 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 2/20 | 0.43 |
| ▸ | CTSD | P07339 | 1/20 | 0.42 |
| ▸ | PLAU | P00749 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10102346 | 0.81 | LMNA (0.55) | MAPK1MAOAMAOBLMNAMAPT | |
| SCHEMBL8980485 | 0.79 | IKBKB (0.53) | MAPK1MAPTKMT2AALDH1A1MEN1 | |
| SCHEMBL30475717 | 0.78 | MAPT (0.45) | CYP19A1LMNAMAPTHTTKMT2A | |
| SCHEMBL6696099 | 0.78 | MAPT (0.45) | CYP19A1LMNAMAPTHTTKMT2A | |
| SCHEMBL2064667 | 0.78 | CES2 (0.61) | MAPK1MAOAMAOBLMNAMAPT | |
| SCHEMBL9196396 | 0.77 | MAPK1 (0.68) | MAPK1CYP19A1LMNAALDH1A1CES2 | |
| SCHEMBL3671244 | 0.76 | POLB (0.54) | MAPK1MAOAMAOBLMNAMAPT | |
| SCHEMBL20185146 | 0.76 | DTYMK (0.54) | CYP19A1LMNAKMT2AALDH1A1MEN1 | |
| SCHEMBL7647310 | 0.75 | DTYMK (0.50) | MAPK1MAOAMAOBMAPTPLAU | |
| SCHEMBL20521709 | 0.75 | ALDH1A1 (0.56) | LMNAMAPTHTTKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5571822-A | AMINO-2-PHENYL-4-QUINOLONE DERIVATIVES | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 1996-11-05 | — | — | US | disclosed |
| WO-1996010563-A1 | 2-ARYL-4-QUINOLONES AS ANTITUMOR COMPOUNDS | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 1996-04-11 | — | — | WO | disclosed |