Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | PARP1 | P09874 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
| ▸ | BLM | P54132 | 1/20 | 0.52 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.51 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.50 |
| ▸ | PLAU | P00749 | 2/20 | 0.50 |
| ▸ | STS | P08842 | 1/20 | 0.50 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.50 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.49 |
| ▸ | KDM1A | O60341 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11633589 | 0.87 | MAPT (0.60) | MAPTL3MBTL1CYP3A4TDP1SRD5A2 | |
| SCHEMBL2426602 | 0.85 | AKR1B1 (0.54) | MAPTL3MBTL1PARP1POLBCYP3A4 | |
| SCHEMBL13381372 | 0.85 | SRD5A2 (0.62) | MAPTL3MBTL1FOLH1SRD5A2ANPEP | |
| SCHEMBL3054667 | 0.83 | PARP1 (0.53) | MAPTL3MBTL1PARP1POLBCYP3A4 | |
| SCHEMBL9379028 | 0.82 | PBRM1 (0.55) | MAPTL3MBTL1CYP3A4TDP1SRD5A2 | |
| SCHEMBL27625881 | 0.82 | LOXL2 (0.51) | MAPTL3MBTL1CYP3A4TSHRCYP2C19 | |
| SCHEMBL2978267 | 0.81 | PLA2G10 (0.63) | MAPTL3MBTL1PARP1POLBCYP3A4 | |
| SCHEMBL10189495 | 0.81 | PARP1 (0.56) | MAPTL3MBTL1PARP1POLBCYP3A4 | |
| SCHEMBL7475229 | 0.81 | AKR1B1 (0.59) | MAPTL3MBTL1CYP3A4TSHRCYP2C19 | |
| SCHEMBL4224616 | 0.81 | PLA2G2A (0.69) | MAPTL3MBTL1PARP1POLBCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050227987-A1 | 11beta-hydroxysteroid dehydrogenase inhibitors | STERIX LIMITED (GB) | 2005-10-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050227987-A1 | 11beta-hydroxysteroid dehydrogenase inhibitors | HSD3B1, HSD3B2, HSD17B3 | MAPT 4512/4885L3MBTL1 1261/4885PARP1 3139/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.