Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.55 |
| ▸ | HPGD | P15428 | 5/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | CASP1 | P29466 | 1/20 | 0.51 |
| ▸ | CASP7 | P55210 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | PLAU | P00749 | 2/20 | 0.48 |
| ▸ | F2 | P00734 | 1/20 | 0.48 |
| ▸ | F10 | P00742 | 1/20 | 0.48 |
| ▸ | PLG | P00747 | 1/20 | 0.48 |
| ▸ | PLAT | P00750 | 1/20 | 0.48 |
| ▸ | KLK1 | P06870 | 1/20 | 0.48 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18646228 | 0.86 | HPGD (0.55) | ALDH1A1HPGDKDM4EHSD17B10ALOX5 | |
| SCHEMBL5221046 | 0.86 | HPGD (0.64) | ALDH1A1HPGDKDM4EMAPTCASP1 | |
| SCHEMBL3923471 | 0.82 | ALOX5 (0.74) | ALDH1A1HPGDKDM4EHSD17B10ALOX5 | |
| SCHEMBL13477779 | 0.82 | ALDH1A1 (0.58) | ALDH1A1HPGDKDM4EHSD17B10ALOX5 | |
| SCHEMBL17689161 | 0.82 | HPGD (0.56) | ALDH1A1HPGDHSD17B10MAPTSMN1; SMN2 | |
| SCHEMBL16771620 | 0.81 | ALOX5 (0.62) | ALDH1A1HPGDKDM4EHSD17B10ALOX5 | |
| SCHEMBL23773211 | 0.81 | HTT (0.55) | ALDH1A1HPGDKDM4EHSD17B10ALOX5 | |
| SCHEMBL9494355 | 0.80 | ALDH1A1 (0.73) | ALDH1A1HPGDKDM4EHSD17B10MAPT | |
| SCHEMBL12260924 | 0.79 | MMP2 (0.55) | ALDH1A1HPGDKDM4EHSD17B10ALOX5 | |
| SCHEMBL8894839 | 0.79 | ALDH1A1 (0.62) | ALDH1A1KDM4EMAPTCASP1CASP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0711286-A1 | BENZOXAZINONES AND BENZOTHIAZINONES ENDOWED WITH THERAPEUTIC ACTIVITY | ITALFARMACO S.p.A. (IT) | 1996-05-15 | — | — | EP | disclosed |
| WO-1995004048-A1 | BENZOXAZINONES AND BENZOTHIAZINONES ENDOWED WITH THERAPEUTIC ACTIVITY | ITALFARMACO S.P.A. (IT) | 1995-02-09 | — | — | WO | disclosed |