Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SGMS2 | Q8NHU3 | 5/20 | 0.70 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 1/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.62 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.59 |
| ▸ | NPC1 | O15118 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 4/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.54 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8980612 | 0.89 | SGMS2 (0.70) | SGMS2LMNAMAPTL3MBTL1HCRTR1 | |
| SCHEMBL1927224 | 0.86 | SGMS2 (0.74) | SGMS2LMNAMAPTL3MBTL1HCRTR1 | |
| SCHEMBL18644999 | 0.84 | SGMS2 (0.72) | SGMS2LMNAMAPTL3MBTL1HCRTR1 | |
| SCHEMBL3018273 | 0.81 | SGMS2 (0.76) | SGMS2LMNAMAPTL3MBTL1NPC1 | |
| SCHEMBL974381 | 0.79 | SGMS2 (0.72) | SGMS2LMNAMAPTL3MBTL1NPC1 | |
| SCHEMBL6748166 | 0.79 | SGMS2 (0.72) | SGMS2LMNAMAPTL3MBTL1NPC1 | |
| SCHEMBL7344495 | 0.79 | SGMS2 (0.59) | SGMS2LMNAMAPTL3MBTL1NPC1 | |
| SCHEMBL22351623 | 0.79 | SGMS2 (0.56) | SGMS2LMNAMAPTL3MBTL1HCRTR1 | |
| SCHEMBL27606875 | 0.79 | SGMS2 (0.64) | SGMS2LMNAMAPTL3MBTL1NPC1 | |
| SCHEMBL18645004 | 0.78 | SGMS2 (0.62) | SGMS2LMNAMAPTL3MBTL1HCRTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1132508-A | Piperazine derivatives | REORDATI IND CHIMICA E FARMACE (CH) | 1996-10-02 | — | — | CN | disclosed |
| EP-0711288-A1 | PIPERAZINE DERIVATIVES AS ALPHA 1A-ADRENERGIC RECEPTOR ANTAGONISTS | RECORDATI INDUSTRIA CHIMICA E FARMACEUTICA S.p.a. (IT) | 1996-05-15 | — | — | EP | disclosed |
| WO-1995004049-A1 | PIPERAZINE DERIVATIVES AS α1A-ADRENERGIC RECEPTOR ANTAGONISTS | RECORDATI S.A., CHEMICAL AND PHARMACEUTICAL COMPANY (CH) | 1995-02-09 | — | — | WO | disclosed |