Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.32 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7434667 | 0.81 | LMNA (0.38) | LMNAGLAALDH1A1MAPTHCRTR1 | |
| SCHEMBL8981227 | 0.74 | CYP1A2 (0.43) | LMNAGLAALDH1A1MAPTHCRTR1 | |
| SCHEMBL9221175 | 0.74 | GLA (0.42) | LMNAGLAALDH1A1MAPTHCRTR1 | |
| SCHEMBL9043191 | 0.72 | LMNA (0.36) | LMNAGLAALDH1A1MAPTHCRTR1 | |
| SCHEMBL7006694 | 0.71 | LMNA (0.41) | LMNAGLAALDH1A1MAPTHCRTR1 | |
| SCHEMBL9045587 | 0.71 | LMNA (0.35) | LMNAGLAALDH1A1MAPTHCRTR1 | |
| SCHEMBL7008374 | 0.71 | LMNA (0.35) | LMNAGLAALDH1A1MAPTHCRTR1 | |
| SCHEMBL8980842 | 0.69 | ALDH1A1 (0.37) | ALDH1A1MAPTCYP1A2CYP1A1CYP1B1 | |
| SCHEMBL8981331 | 0.68 | MYC (0.36) | — | |
| SCHEMBL27525583 | 0.68 | LMNA (0.38) | LMNAGLAALDH1A1MAPTHCRTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5484937-A | ANGIOTENSIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1996-01-16 | — | — | US | disclosed |
| US-5175180-A | Antagonist, antagonism | G. D. SEARLE & CO. (US) | 1992-12-29 | — | — | US | disclosed |
| WO-1992011255-A1 | N-SUBSTITUTED N-(α-TRIAZOLYL-TOLUYL)PYRROLE COMPOUNDS FOR TREATMENT OF CIRCULATORY DISORDERS | G.D. SEARLE & CO. (US) | 1992-07-09 | — | — | WO | disclosed |