Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 3/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.39 |
| ▸ | MGLL | Q99685 | 1/20 | 0.36 |
| ▸ | CTSB | P07858 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | G6PD | P11413 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2536276 | 0.83 | GABRA1 (0.41) | GABRA1GABRB2TSHRMEN1POLB | |
| SCHEMBL10939611 | 0.80 | GABRA1 (0.38) | GABRA1GABRB2MGLLCTSBMAPT | |
| SCHEMBL13813494 | 0.79 | GABRA1 (0.41) | GABRA1GABRB2MGLLCTSBMAPT | |
| SCHEMBL344617 | 0.77 | PTK2B (0.46) | GABRA1GABRB2TSHRPOLB | |
| SCHEMBL20526222 | 0.77 | GABRA1 (0.44) | GABRA1GABRB2TSHRPOLB | |
| SCHEMBL30480017 | 0.77 | CA2 (0.35) | TSHRMEN1POLBKMT2A | |
| SCHEMBL10874191 | 0.77 | GABRA1 (0.40) | GABRA1GABRB2MGLLCTSBMAPT | |
| Hydrochloric Acid SCHEMBL10824664 | 0.76 | PTK2B (0.44) | GABRA1GABRB2TSHRPOLB | |
| SCHEMBL28944501 | 0.76 | GABRA1 (0.38) | GABRA1GABRB2MGLLCTSBMAPT | |
| Zinc Ion SCHEMBL916285 | 0.76 | GABRA1 (0.38) | GABRA1GABRB2MGLLCTSBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0711288-A1 | PIPERAZINE DERIVATIVES AS ALPHA 1A-ADRENERGIC RECEPTOR ANTAGONISTS | RECORDATI INDUSTRIA CHIMICA E FARMACEUTICA S.p.a. (IT) | 1996-05-15 | — | — | EP | disclosed |
| WO-1995004049-A1 | PIPERAZINE DERIVATIVES AS α1A-ADRENERGIC RECEPTOR ANTAGONISTS | RECORDATI S.A., CHEMICAL AND PHARMACEUTICAL COMPANY (CH) | 1995-02-09 | — | — | WO | disclosed |