Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.53 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.53 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.53 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.53 |
| ▸ | CDK1 | P06493 | 1/20 | 0.51 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.51 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.51 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.51 |
| ▸ | CA12 | O43570 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | CA3 | P07451 | 1/20 | 0.49 |
| ▸ | CA4 | P22748 | 1/20 | 0.49 |
| ▸ | CA6 | P23280 | 1/20 | 0.49 |
| ▸ | CA5A | P35218 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6714042 | 0.91 | AKR1C4 (0.58) | ALDH1A1KDM4EMAPTAKR1C4AKR1C3 | |
| SCHEMBL13320226 | 0.86 | AKR1C4 (0.56) | ALDH1A1AKR1C4AKR1C3AKR1C2AKR1C1 | |
| SCHEMBL10705372 | 0.82 | ALDH1A1 (0.53) | ALDH1A1KDM4EMAPTCDK1CA12 | |
| SCHEMBL19325533 | 0.81 | AKR1C4 (0.47) | ALDH1A1AKR1C4AKR1C3AKR1C2AKR1C1 | |
| SCHEMBL2454782 | 0.81 | AKR1C4 (0.55) | ALDH1A1AKR1C4AKR1C3AKR1C2AKR1C1 | |
| SCHEMBL19325836 | 0.81 | AKR1C4 (0.55) | ALDH1A1KDM4EMAPTAKR1C4AKR1C3 | |
| SCHEMBL15535669 | 0.80 | NAAA (0.55) | ALDH1A1AKR1C4AKR1C3AKR1C2AKR1C1 | |
| SCHEMBL29548347 | 0.80 | NAAA (0.55) | ALDH1A1AKR1C4AKR1C3AKR1C2AKR1C1 | |
| SCHEMBL15887754 | 0.80 | NAAA (0.55) | ALDH1A1AKR1C4AKR1C3AKR1C2AKR1C1 | |
| SCHEMBL13545500 | 0.79 | FABP4 (0.55) | ALDH1A1KDM4EAKR1C4AKR1C3AKR1C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0711286-A1 | BENZOXAZINONES AND BENZOTHIAZINONES ENDOWED WITH THERAPEUTIC ACTIVITY | ITALFARMACO S.p.A. (IT) | 1996-05-15 | — | — | EP | disclosed |
| WO-1995004048-A1 | BENZOXAZINONES AND BENZOTHIAZINONES ENDOWED WITH THERAPEUTIC ACTIVITY | ITALFARMACO S.P.A. (IT) | 1995-02-09 | — | — | WO | disclosed |