Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 5/20 | 0.49 |
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
| ▸ | CES1 | P23141 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | DAO | P14920 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.36 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.36 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.36 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9547515 | 0.83 | ALOX5 (0.44) | ALOX5CES2CES1POLBDAO | |
| SCHEMBL9850025 | 0.79 | ALOX5 (0.46) | ALOX5CES2CES1POLBDAO | |
| SCHEMBL28723722 | 0.75 | CES2 (0.39) | ALOX5CES2CES1POLBDAO | |
| SCHEMBL5891695 | 0.75 | ALOX5 (0.42) | ALOX5CES2CES1POLBDAO | |
| SCHEMBL7765615 | 0.75 | POLB (0.39) | ALOX5CES2CES1POLBDAO | |
| SCHEMBL7682897 | 0.74 | — | — | |
| SCHEMBL9547570 | 0.73 | CES2 (0.44) | ALOX5CES2CES1POLBDAO | |
| SCHEMBL16334418 | 0.72 | DAO (0.43) | ALOX5CES2CES1POLBDAO | |
| SCHEMBL3836356 | 0.72 | ALOX5 (0.47) | ALOX5DAOALDH1A1MEN1NPC1 | |
| SCHEMBL4683609 | 0.72 | HPGDS (0.43) | ALOX5CES2CES1POLBDAO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996028156-A1 | NOVEL BENZOTHIOPHENE COMPOUNDS AND METHODS | ELI LILLY AND COMPANY (US) | 1996-09-19 | — | — | WO | disclosed |
| EP-0732331-A1 | Novel benzothiophene compounds and methods for inhibiting lipoxygenase and leukotrienes | ELI LILLY AND COMPANY (US) | 1996-09-18 | — | — | EP | disclosed |
| US-5532382-A | INHIBITOR OF LIPOXYGENASE AND LEUKOTRIENES; | ELI LILLY AND COMPANY (US) | 1996-07-02 | — | — | US | disclosed |
| US-5514703-A | INTERRUPTION OF LEUKOTRIENE PATHWAY | ELI LILLY AND COMPANY (US) | 1996-05-07 | — | — | US | disclosed |
| US-5514704-A | AND LIPOXYGENASE | ELI LILLY AND COMPANY (US) | 1996-05-07 | — | — | US | disclosed |
| US-5356921-A | Exhibit 5-lipoxygenase and thromboxane synthase inhibiting activities; administering for disorders attributable to the action of leukotrienes and thromboxane A2 | GRUENENTHAL GMBH (DE) | 1994-10-18 | — | — | US | disclosed |
| EP-0588785-A1 | UREA BASED LIPOXYGENASE INHIBITING COMPOUNDS | ABBOTT LABORATORIES (US) | 1994-03-30 | — | — | EP | disclosed |
| US-5185363-A | Administering for treatment of inflammatory diseases | ABBOTT LABORATORIES (US) | 1993-02-09 | — | — | US | disclosed |
| CN-1066062-A | Medicinal compound | LILLY CO ELI (US) | 1992-11-11 | — | — | CN | disclosed |
| CN-1066060-A | Medicinal compound | LILLY CO ELI (US) | 1992-11-11 | — | — | CN | disclosed |
| EP-0588785-A4 | UREA BASED LIPOXYGENASE INHIBITING COMPOUNDS. | ABBOTT LAB (US) | 1991-12-30 | — | — | EP | disclosed |
| WO-1990012008-A1 | UREA BASED LIPOXYGENASE INHIBITING COMPOUNDS | ABBOTT LABORATORIES (US) | 1990-10-18 | — | — | WO | disclosed |