Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MBOAT4 | Q96T53 | 1/20 | 0.54 |
| ▸ | NAMPT | P43490 | 1/20 | 0.45 |
| ▸ | TYMS | P04818 | 6/20 | 0.44 |
| ▸ | DHFR | P00374 | 4/20 | 0.44 |
| ▸ | FOLR2 | P14207 | 1/20 | 0.39 |
| ▸ | FOLR1 | P15328 | 1/20 | 0.39 |
| ▸ | GART | P22102 | 1/20 | 0.39 |
| ▸ | ATIC | P31939 | 1/20 | 0.39 |
| ▸ | SHMT1 | P34896 | 1/20 | 0.39 |
| ▸ | SLC19A1 | P41440 | 1/20 | 0.39 |
| ▸ | FRK | P42685 | 1/20 | 0.39 |
| ▸ | SLC46A1 | Q96NT5 | 1/20 | 0.39 |
| ▸ | RARB | P10826 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8982456 | 0.89 | CYP4A11 (0.48) | MBOAT4NAMPTTYMSDHFR | |
| SCHEMBL7836419 | 0.88 | NAMPT (0.56) | MBOAT4NAMPTTYMSDHFR | |
| SCHEMBL8982512 | 0.82 | DHFR (0.71) | TYMSDHFRFOLR2FOLR1GART | |
| SCHEMBL9045691 | 0.81 | TYMS (0.48) | NAMPTTYMSDHFRFOLR2FOLR1 | |
| SCHEMBL8802138 | 0.81 | NAMPT (0.63) | MBOAT4NAMPTTYMSDHFRFOLR2 | |
| SCHEMBL7846955 | 0.80 | TYMS (0.66) | TYMSDHFRFOLR2FOLR1GART | |
| SCHEMBL9844826 | 0.79 | CYP4A11 (0.49) | TYMSDHFR | |
| SCHEMBL9085311 | 0.79 | NAMPT (0.53) | NAMPTTYMSDHFR | |
| SCHEMBL9044536 | 0.78 | NAMPT (0.51) | NAMPTTYMSDHFR | |
| SCHEMBL9848004 | 0.77 | DHFR (0.53) | TYMSDHFRFOLR2FOLR1GART |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5496822-A | Compounds and methods for treating tumors | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-03-05 | — | — | US | disclosed |
| EP-0434426-A1 | Condensed heterocyclic compounds, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1991-06-26 | — | — | EP | disclosed |