Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.47 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | MMP8 | P22894 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | TARBP2 | Q15633 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11839075 | 0.95 | HTT (0.47) | MAPTKMT2ALMNANPSR1MEN1 | |
| SCHEMBL13557323 | 0.85 | MEN1 (0.47) | KMT2ALMNAMEN1GAACYP1A2 | |
| SCHEMBL20930834 | 0.85 | KMT2A (0.50) | MAPTKMT2ALMNANPSR1MEN1 | |
| SCHEMBL5209865 | 0.83 | ESR1 (0.53) | MAPTKMT2ALMNAGAACYP1A2 | |
| SCHEMBL11598177 | 0.83 | LMNA (0.49) | MAPTKMT2ALMNANPSR1MEN1 | |
| SCHEMBL13924144 | 0.83 | SMN1; SMN2 (0.50) | KMT2ALMNAMEN1GAAHTT | |
| SCHEMBL5209871 | 0.83 | ESR1 (0.53) | MAPTKMT2ALMNAGAACYP1A2 | |
| SCHEMBL536847 | 0.83 | MMP8 (0.56) | MAPTKMT2ALMNANPSR1MEN1 | |
| SCHEMBL4718293 | 0.82 | MAPT (0.45) | MAPTKMT2ALMNANPSR1MEN1 | |
| SCHEMBL15918195 | 0.82 | CASP1 (0.54) | MAPTKMT2ALMNANPSR1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3814331-B1 | NOVEL LXR MODULATORS WITH BICYCLIC CORE MOIETY | ORSOBIO INC (US) | 2023-06-14 | — | — | EP | disclosed |
| WO-2013130370-A2 | COMPOUNDS AS DGAT-1 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2013-09-06 | — | — | WO | disclosed |
| WO-2012044567-A2 | IMIDAZOLE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2012-04-05 | — | — | WO | disclosed |