Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 2/20 | 0.51 |
| ▸ | TMEM97 | Q5BJF2 | 3/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.48 |
| ▸ | DRD3 | P35462 | 4/20 | 0.47 |
| ▸ | DRD4 | P21917 | 2/20 | 0.47 |
| ▸ | DRD2 | P14416 | 2/20 | 0.47 |
| ▸ | DRD1 | P21728 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HTR7 | P34969 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4234369 | 0.99 | ABCB1 (0.50) | ABCB1TMEM97SIGMAR1DRD3DRD4 | |
| SCHEMBL10035600 | 0.97 | ABCB1 (0.49) | ABCB1TMEM97SIGMAR1KMT2AHTR7 | |
| SCHEMBL4223947 | 0.96 | ABCB1 (0.51) | ABCB1TMEM97SIGMAR1DRD3DRD4 | |
| Hydrochloric Acid SCHEMBL2138408 | 0.96 | ABCB1 (0.48) | ABCB1TMEM97SIGMAR1KMT2AHTR7 | |
| SCHEMBL4218972 | 0.95 | ABCB1 (0.50) | ABCB1TMEM97SIGMAR1DRD3DRD4 | |
| SCHEMBL4223248 | 0.93 | ABCB1 (0.52) | ABCB1TMEM97SIGMAR1DRD3DRD4 | |
| SCHEMBL2139395 | 0.93 | KMT2A (0.52) | ABCB1TMEM97SIGMAR1KMT2AHTR7 | |
| Hydrochloric Acid SCHEMBL4222766 | 0.93 | ABCB1 (0.51) | ABCB1TMEM97SIGMAR1DRD3DRD4 | |
| SCHEMBL4232121 | 0.93 | ABCB1 (0.51) | ABCB1TMEM97SIGMAR1DRD3DRD4 | |
| SCHEMBL4363006 | 0.92 | ABCB1 (0.55) | ABCB1TMEM97SIGMAR1DRD3DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8188115-B2 | 5-HT7 receptor antagonists | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2012-05-29 | — | — | US | disclosed |
| US-8188115-B2 | 5-HT7 receptor antagonists | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2012-05-29 | — | — | US | disclosed |
| US-20090163542-A1 | 5-ht7 receptor antagonists | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2009-06-25 | — | — | US | disclosed |
| US-20090163542-A1 | 5-ht7 receptor antagonists | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2009-06-25 | — | — | US | disclosed |
| US-7211585-B2 | 5-HT7 receptor antagonists | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2007-05-01 | — | — | US | disclosed |
| US-7211585-B2 | 5-HT7 receptor antagonists | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2007-05-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090163542-A1 | 5-ht7 receptor antagonists | HTR7, HTR1A, HTR5A | ABCB1 528/4885TMEM97 100/4885SIGMAR1 140/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.