Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MT-CO2 | P00403 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.39 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.39 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.39 |
| ▸ | FLT1 | P17948 | 1/20 | 0.39 |
| ▸ | FLT4 | P35916 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.37 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9875354 | 0.98 | MT-CO2 (0.44) | MT-CO2POLBKMT2AMEN1TAS1R3 | |
| SCHEMBL9874246 | 0.91 | TAS1R3 (0.41) | MT-CO2KMT2AMEN1TAS1R3TAS1R1 | |
| SCHEMBL9686975 | 0.80 | MT-CO2 (0.41) | MT-CO2POLBKMT2AMEN1ALDH1A1 | |
| SCHEMBL10673681 | 0.80 | MT-CO2 (0.55) | MT-CO2POLBKMT2AMEN1ALDH1A1 | |
| SCHEMBL9875536 | 0.80 | MT-CO2 (0.55) | MT-CO2POLBKMT2AMEN1GAA | |
| SCHEMBL9875746 | 0.80 | MT-CO2 (0.41) | MT-CO2POLBKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL9876109 | 0.80 | MT-CO2 (0.41) | MT-CO2POLBKMT2AMEN1GAA | |
| Hydrochloric Acid SCHEMBL9874997 | 0.79 | MT-CO2 (0.54) | MT-CO2POLBKMT2AMEN1GAA | |
| Hydrochloric Acid SCHEMBL9875471 | 0.79 | MT-CO2 (0.54) | MT-CO2POLBKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL9013009 | 0.78 | POLB (0.37) | MT-CO2POLBKMT2AMEN1FLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4754050-A | COGNITION ACTIVATORS | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1988-06-28 | — | — | US | claimed |
| JP-1125362-A | — | — | None | — | — | JP | disclosed |
| EP-0449172-B1 | A method of reducing a carbonyl containing acridine | HOECHST ROUSSEL PHARMA (US) | 1996-06-05 | — | — | EP | disclosed |
| EP-0581194-A1 | A process for the preparation of enamines in aqueous media | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1994-02-02 | — | — | EP | disclosed |
| US-5247091-A | Preparation of enamines in aqueous media | HOECHST CELANESE CORPORATION (US) | 1993-09-21 | — | — | US | disclosed |
| EP-0449172-A1 | A method of reducing a carbonyl containing acridine | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1991-10-02 | — | — | EP | disclosed |
| US-5053513-A | Catalytic hydrogenation using noble metal catalyst, lithium hydroxide, solvent | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1991-10-01 | — | — | US | disclosed |
| EP-0179383-B1 | 9-AMINO-1,2,3,4-TETRAHYDROACRIDIN-1-OL AND RELATED COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1991-05-29 | — | — | EP | disclosed |
| US-4839364-A | ALZHEIMER*S DISEASE; CHOLINESTERASE INHIBITORS | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1989-06-13 | — | — | US | disclosed |
| US-4835275-A | Method of preparing 9-amino-1,2,3,4,-tetrahydroacridin-1-ones and related compounds | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1989-05-30 | — | — | US | disclosed |
| JP-H01125362-A | 2-(3-OXOCYCLOHEXENE-1-YL)AMINOBENZONITRILE AND ITS DERIVATIVE | HOECHST ROUSSEL PHARMACEUT INC | 1989-05-17 | — | — | JP | disclosed |
| US-4754050-A | COGNITION ACTIVATORS | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1988-06-28 | — | — | US | disclosed |
| US-4695573-A | COGNITION ACTIVATORS | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1987-09-22 | — | — | US | disclosed |
| US-4631286-A | MEMORY ENHANCERS | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1986-12-23 | — | — | US | disclosed |
| EP-0179383-A2 | 9-Amino-1,2,3,4-tetrahydroacridin-1-ol and related compounds, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1986-04-30 | — | — | EP | disclosed |