SCHEMBL8984231

SCHEMBL8984231

C=CCc1ccc(CC(=S)N2CCOCC2)cc1

nearest known ligand 0.66

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
MGLL Q99685 6/20 0.66
ALDH1A1 P00352 5/20 0.66
FAAH O00519 3/20 0.66
MAPT P10636 5/20 0.61
HPGD P15428 3/20 0.61
GAA P10253 1/20 0.61
APOBEC3G Q9HC16 1/20 0.61
KMT2A Q03164 2/20 0.53
MEN1 O00255 1/20 0.53
CYP2C19 P33261 1/20 0.53
NQO1 P15559 1/20 0.46
KDM4E B2RXH2 1/20 0.41
ALOX15 P16050 1/20 0.41
HSD17B10 Q99714 1/20 0.41
NPSR1 Q6W5P4 1/20 0.38
NPC1 O15118 1/20 0.38
PKM P14618 1/20 0.38
RAB9A P51151 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4397261 0.80 ALDH1A1 (1.00) MGLLALDH1A1FAAHMAPTHPGD
SCHEMBL4399380 0.80 ALDH1A1 (1.00) MGLLALDH1A1FAAHMAPTHPGD
SCHEMBL1108678 0.79 MGLL (0.82) MGLLALDH1A1FAAHMAPTHPGD
SCHEMBL12590360 0.77 ALDH1A1 (0.72) MGLLALDH1A1FAAHMAPTHPGD
SCHEMBL19380615 0.77 MGLL (1.00) MGLLALDH1A1FAAHMAPTHPGD
SCHEMBL6978893 0.77 ALDH1A1 (0.62) MGLLALDH1A1FAAHMAPTHPGD
SCHEMBL4391501 0.76 ALDH1A1 (0.68) MGLLALDH1A1FAAHMAPTHPGD
SCHEMBL4394405 0.76 ALDH1A1 (1.00) MGLLALDH1A1FAAHMAPTHPGD
SCHEMBL4391628 0.76 ALDH1A1 (0.70) MGLLALDH1A1FAAHMAPTHPGD
SCHEMBL11862607 0.75 ALDH1A1 (0.61) MGLLALDH1A1FAAHMAPTHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0339252-B1 2,5-disubstituted pyrazine derivatives, pyrimidine derivatives, and liquid crystal containing the same DAINIPPON INK & CHEMICALS (JP) 1996-06-12 EP disclosed
US-5128472-A Electrooptical display materials, ferroelectric display DAINIPPON INK AND CHEMICALS, INC. (JP) 1992-07-07 US disclosed
US-4997942-A 2,4-disubstituted pyrazine derivatives, pyrimidine derivatives, and liquid crystal containing the same DAINIPPON INK AND CHEMICAL, INC. (JP) 1991-03-05 US disclosed