SCHEMBL8985174

SCHEMBL8985174

N#CNC1(NC#N)C=CC(C(=O)Nc2ccccc2)C=C1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 4/20 0.41
KMT2A Q03164 4/20 0.41
SMN1; SMN2 Q16637 4/20 0.41
MAPT P10636 3/20 0.41
KDM4E B2RXH2 3/20 0.41
ALDH1A1 P00352 1/20 0.41
HPGD P15428 1/20 0.41
HDAC6 Q9UBN7 2/20 0.40
TOP2A P11388 1/20 0.40
SLC22A12 Q96S37 1/20 0.40
POLB P06746 2/20 0.40
GAA P10253 2/20 0.40
GFER P55789 1/20 0.40
TP53 P04637 1/20 0.39
EPHX1 P07099 1/20 0.39
TSHR P16473 1/20 0.39
EPHX2 P34913 1/20 0.39
CDK9 P50750 1/20 0.39
CLK4 Q9HAZ1 1/20 0.39
F13A1 P00488 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10339863 0.79 HPGD (0.46) MEN1KMT2ASMN1; SMN2MAPTHPGD
SCHEMBL8985137 0.78 ALDH1A1 (0.36) MEN1KMT2ASMN1; SMN2MAPTKDM4E
SCHEMBL11219965 0.78 HPGD (0.45) MEN1KMT2ASMN1; SMN2MAPTHPGD
SCHEMBL1413119 0.78 F13A1 (0.46) MEN1KMT2ASMN1; SMN2MAPTHPGD
SCHEMBL1404328 0.75 TOP2A (0.42) MEN1KMT2ASMN1; SMN2MAPTKDM4E
SCHEMBL9262914 0.75 MEN1 (0.42) MEN1KMT2ASMN1; SMN2MAPTALDH1A1
SCHEMBL9271641 0.74 POLB (0.41) MEN1KMT2ASMN1; SMN2MAPTALDH1A1
SCHEMBL9423167 0.71 F13A1 (0.40) MEN1KMT2ASMN1; SMN2MAPTKDM4E
SCHEMBL6865135 0.69 F13A1 (0.38) MEN1KMT2ASMN1; SMN2MAPTHPGD
SCHEMBL9746506 0.67 F13A1 (0.40) MEN1KMT2ASMN1; SMN2MAPTKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0476589-B1 Multi-layer wiring substrate and production thereof HITACHI LTD (JP) 1996-06-12 EP disclosed
EP-0476589-A2 Multi-layer wiring substrate and production thereof HITACHI, LTD. (JP) 1992-03-25 EP disclosed