Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 10/20 | 0.56 |
| ▸ | PTGS1 | P23219 | 5/20 | 0.56 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.50 |
| ▸ | IKBKB | O14920 | 2/20 | 0.46 |
| ▸ | CHUK | O15111 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MT-CO1 | P00395 | 1/20 | 0.45 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | CDC7 | O00311 | 1/20 | 0.44 |
| ▸ | PLK4 | O00444 | 1/20 | 0.44 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.44 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8985442 | 0.89 | MAPK14 (0.64) | PTGS2PTGS1MAPK14KDM4EMT-CO1 | |
| SCHEMBL8985285 | 0.87 | PTGS2 (0.52) | PTGS2PTGS1MAPK14IKBKBKDM4E | |
| SCHEMBL8985502 | 0.86 | PTGS2 (0.51) | PTGS2PTGS1MAPK14KDM4EMT-CO1 | |
| SCHEMBL8985461 | 0.84 | PTGS2 (0.68) | PTGS2PTGS1MAPK14KDM4EMT-CO1 | |
| SCHEMBL8985292 | 0.79 | MAPK14 (0.57) | PTGS2PTGS1MAPK14IKBKBCHUK | |
| SCHEMBL8985348 | 0.78 | PTGS2 (0.51) | PTGS2PTGS1KDM4EMT-CO1MT-CO2 | |
| SCHEMBL8985500 | 0.75 | PTGS2 (0.50) | PTGS2PTGS1MAPK14KDM4EMT-CO1 | |
| SCHEMBL8985366 | 0.74 | MAPK14 (0.51) | PTGS2PTGS1MAPK14TSHRCDC7 | |
| SCHEMBL14566255 | 0.74 | IKBKB (0.80) | IKBKBCHUK | |
| SCHEMBL8985516 | 0.73 | MAPK14 (0.83) | PTGS2PTGS1MAPK14KDM4EMT-CO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5571810-A | ANTIINFLAMMATORY AGENTS, ANALGESICS, COLLAGEN DISEASES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-11-05 | — | — | US | disclosed |
| EP-0593761-A1 | NEW THIOPHENE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1994-04-27 | — | — | EP | disclosed |
| WO-1991019708-A1 | NEW THIOPHENE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-12-26 | — | — | WO | disclosed |