Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 8/20 | 0.57 |
| ▸ | PTGS2 | P35354 | 8/20 | 0.52 |
| ▸ | PTGS1 | P23219 | 5/20 | 0.52 |
| ▸ | CDC7 | O00311 | 1/20 | 0.51 |
| ▸ | PLK4 | O00444 | 1/20 | 0.51 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.51 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.51 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.51 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.51 |
| ▸ | CDK1 | P06493 | 1/20 | 0.51 |
| ▸ | FES | P07332 | 1/20 | 0.51 |
| ▸ | ROS1 | P08922 | 1/20 | 0.51 |
| ▸ | PIM1 | P11309 | 1/20 | 0.51 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.51 |
| ▸ | FER | P16591 | 1/20 | 0.51 |
| ▸ | PRKACA | P17612 | 1/20 | 0.51 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.51 |
| ▸ | CDK2 | P24941 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | KDR | P35968 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8985250 | 0.87 | MAPK14 (0.73) | MAPK14PTGS2PTGS1CYP1A2CYP3A4 | |
| SCHEMBL8985225 | 0.85 | MAPK14 (0.55) | MAPK14PTGS2PTGS1CYP1A2CYP3A4 | |
| SCHEMBL8985206 | 0.83 | MAPK14 (0.54) | MAPK14PTGS2PTGS1PLK1IKBKB | |
| SCHEMBL8985461 | 0.82 | PTGS2 (0.68) | MAPK14PTGS2PTGS1CHEK2CDK1 | |
| SCHEMBL8985366 | 0.82 | MAPK14 (0.51) | MAPK14PTGS2PTGS1CDC7PLK4 | |
| SCHEMBL8985342 | 0.80 | MAPK14 (0.83) | MAPK14PTGS2PTGS1CYP1A2CYP3A4 | |
| SCHEMBL8985287 | 0.79 | PTGS2 (0.56) | MAPK14PTGS2PTGS1CDC7PLK4 | |
| SCHEMBL8985516 | 0.78 | MAPK14 (0.83) | MAPK14PTGS2PTGS1CYP1A2CYP3A4 | |
| SCHEMBL8985467 | 0.78 | MAPK14 (0.60) | MAPK14PTGS2PTGS1CYP1A2CYP3A4 | |
| SCHEMBL11180671 | 0.76 | MAPK14 (0.59) | MAPK14PTGS2PTGS1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5571810-A | ANTIINFLAMMATORY AGENTS, ANALGESICS, COLLAGEN DISEASES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-11-05 | — | — | US | disclosed |
| EP-0593761-A1 | NEW THIOPHENE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1994-04-27 | — | — | EP | disclosed |