Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 1/20 | 0.51 |
| ▸ | PTGS2 | P35354 | 9/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.46 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | MT-CO1 | P00395 | 1/20 | 0.42 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | GHSR | Q92847 | 1/20 | 0.38 |
| ▸ | ERN1 | O75460 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8985434 | 0.89 | MAPK14 (0.52) | MAPK14PTGS2PTGS1OPRD1KDM4E | |
| SCHEMBL8985524 | 0.86 | MAPK14 (0.51) | MAPK14PTGS2PTGS1OPRD1KDM4E | |
| SCHEMBL8985469 | 0.85 | AURKA (0.47) | PTGS2PTGS1OPRD1KDM4EHPGD | |
| SCHEMBL8985473 | 0.83 | MAPK14 (0.56) | MAPK14PTGS2PTGS1OPRD1KDM4E | |
| SCHEMBL8985407 | 0.82 | MAPK14 (0.51) | MAPK14PTGS2PTGS1OPRD1KDM4E | |
| SCHEMBL8985275 | 0.81 | MAPK14 (0.53) | MAPK14PTGS2PTGS1OPRD1GAA | |
| SCHEMBL8985260 | 0.80 | PTGS2 (0.65) | PTGS2PTGS1KDM4EHPGDMT-CO1 | |
| SCHEMBL8985189 | 0.77 | PTGS2 (0.49) | PTGS2PTGS1KDM4EHPGDMT-CO1 | |
| SCHEMBL7617599 | 0.74 | PTGS2 (0.64) | PTGS2PTGS1OPRD1KDM4EHPGD | |
| SCHEMBL8985532 | 0.73 | MAPK14 (0.53) | MAPK14PTGS2PTGS1OPRD1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5571810-A | ANTIINFLAMMATORY AGENTS, ANALGESICS, COLLAGEN DISEASES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-11-05 | — | — | US | disclosed |
| EP-0593761-A1 | NEW THIOPHENE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1994-04-27 | — | — | EP | disclosed |
| WO-1991019708-A1 | NEW THIOPHENE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-12-26 | — | — | WO | disclosed |