Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 1/20 | 0.56 |
| ▸ | PTGS2 | P35354 | 9/20 | 0.51 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8985275 | 0.86 | MAPK14 (0.53) | MAPK14PTGS2PTGS1PRKCZGAA | |
| SCHEMBL8985434 | 0.84 | MAPK14 (0.52) | MAPK14PTGS2PTGS1HSD17B10ALDH1A1 | |
| SCHEMBL8985304 | 0.83 | PTGS2 (0.55) | MAPK14PTGS2PTGS1HSD17B10OPRD1 | |
| SCHEMBL8985407 | 0.83 | MAPK14 (0.51) | MAPK14PTGS2PTGS1HSD17B10ALDH1A1 | |
| SCHEMBL8985406 | 0.83 | MAPK14 (0.51) | MAPK14PTGS2PTGS1HSD17B10ALDH1A1 | |
| SCHEMBL8985268 | 0.83 | MAPK14 (0.57) | MAPK14PTGS2PTGS1HSD17B10ALDH1A1 | |
| SCHEMBL6018669 | 0.78 | MAPK14 (0.65) | MAPK14HSD17B10ALDH1A1MEN1NPC1 | |
| SCHEMBL7617599 | 0.76 | PTGS2 (0.64) | PTGS2PTGS1HSD17B10ALDH1A1NPC1 | |
| SCHEMBL8985217 | 0.76 | PTGS2 (0.55) | MAPK14PTGS2PTGS1HSD17B10ALDH1A1 | |
| SCHEMBL8985408 | 0.75 | PTGS2 (0.52) | MAPK14PTGS2PTGS1HSD17B10NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5571810-A | ANTIINFLAMMATORY AGENTS, ANALGESICS, COLLAGEN DISEASES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-11-05 | — | — | US | disclosed |
| EP-0593761-A1 | NEW THIOPHENE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1994-04-27 | — | — | EP | disclosed |
| WO-1991019708-A1 | NEW THIOPHENE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-12-26 | — | — | WO | disclosed |