SCHEMBL8986404

SCHEMBL8986404

CC(Oc1cccc(Br)n1)C(=O)O

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.44
GAA P10253 1/20 0.44
CYP2C9 P11712 1/20 0.44
PKM P14618 1/20 0.44
CYP2C19 P33261 1/20 0.44
KMT2A Q03164 1/20 0.44
PPARG P37231 2/20 0.41
PPARA Q07869 2/20 0.41
HTR7 P34969 1/20 0.41
TDP1 Q9NUW8 1/20 0.40
CDK9 P50750 1/20 0.40
DYRK1A Q13627 1/20 0.40
DYRK2 Q92630 1/20 0.40
TSHR P16473 2/20 0.36
HTR2A P28223 1/20 0.36
HTR2C P28335 1/20 0.36
HTR2B P41595 1/20 0.36
ALDH1A1 P00352 3/20 0.35
HPGD P15428 3/20 0.35
KDM4E B2RXH2 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7589 0.78 HTR7 (0.47) CYP1A2CYP2C9CYP2C19KMT2AHTR7
SCHEMBL11204613 0.78 CYP1A2 (0.53) CYP1A2GAACYP2C9PKMCYP2C19
SCHEMBL10661874 0.75 CYP1A2 (0.50) CYP1A2GAACYP2C9PKMCYP2C19
SCHEMBL1249387 0.73 SLC16A3 (0.38) CYP1A2GAACYP2C9PKMCYP2C19
SCHEMBL248107 0.73 HTR7 (0.42) CYP1A2GAAHTR7TDP1TSHR
SCHEMBL5517722 0.72 CYP1A2 (0.50) CYP1A2GAACYP2C9PKMCYP2C19
SCHEMBL1041399 0.72 ALDH1A1 (0.51) CYP1A2GAACYP2C9PKMCYP2C19
SCHEMBL27585578 0.72 HTR7 (0.45) HTR7TDP1TSHRALDH1A1HPGD
SCHEMBL907708 0.71 CYP1A2 (0.45) CYP1A2GAACYP2C9PKMCYP2C19
SCHEMBL29576132 0.71 HTR7 (0.43) HTR7CDK9DYRK1ADYRK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0441457-B1 Preparation of higher alkyl esters of carboxylic acids DOWELANCO (US) 1996-06-05 EP disclosed
CN-1031566-C Preparation of higher alkyl esters of carboxylic acids DOWELANCO CORP (US) 1996-04-17 CN disclosed
US-5214150-A Preparation of higher alkylesters of carboxylic acids DOWELANCO (US) 1993-05-25 US disclosed
CN-1054420-A The method for preparing the carboxylic acid higher alkyl esters DOWELANCO (US) 1991-09-11 CN disclosed
EP-0441457-A2 Preparation of higher alkyl esters of carboxylic acids DOWELANCO (US) 1991-08-14 EP disclosed