Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.58 |
| ▸ | ABL1 | P00519 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | NAMPT | P43490 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8986417 | 0.91 | NAMPT (0.65) | MAPTTDP1ABL1POLBRIN1 | |
| SCHEMBL1996211 | 0.84 | NAMPT (0.57) | MAPTABL1RIN1LMNAHTT | |
| SCHEMBL1996214 | 0.84 | NAMPT (0.57) | MAPTABL1RIN1LMNAHTT | |
| SCHEMBL7300880 | 0.84 | LMNA (0.49) | MAPTTDP1ABL1POLBRIN1 | |
| SCHEMBL8986418 | 0.83 | LMNA (0.61) | LMNAHTTCYP2C19ALDH1A1HPGD | |
| SCHEMBL10813817 | 0.83 | LMNA (0.61) | LMNAHTTCYP2C19ALDH1A1HPGD | |
| SCHEMBL7985522 | 0.82 | KDM1A (0.59) | POLBHTTCYP2C19 | |
| SCHEMBL27322968 | 0.82 | LMNA (0.47) | MAPTTDP1ABL1POLBRIN1 | |
| SCHEMBL11437380 | 0.81 | MEN1 (0.50) | MAPTLMNAHTTKMT2AALDH1A1 | |
| SCHEMBL10156800 | 0.80 | NAMPT (0.60) | MAPTABL1RIN1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5574055-A | COGNITIVE AND NEURODEGENERATIVE DISORDERS | HOFFMANN-LA ROCHE INC. (US) | 1996-11-12 | — | — | US | disclosed |