Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | CRHBP | P24387 | 1/20 | 0.44 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
| ▸ | MMP9 | P14780 | 1/20 | 0.42 |
| ▸ | MMP8 | P22894 | 1/20 | 0.42 |
| ▸ | MMP14 | P50281 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7305192 | 0.90 | NAMPT (0.47) | LMNAMAPTMAPK1SLC18A3SMN1; SMN2 | |
| SCHEMBL27322968 | 0.88 | LMNA (0.47) | LMNAMAPTMAPK1SLC18A3HPGD | |
| SCHEMBL8986471 | 0.84 | MAPT (0.58) | LMNAMAPTHPGDABL1POLB | |
| SCHEMBL10813817 | 0.80 | LMNA (0.61) | LMNASMN1; SMN2HPGDCYP1A2NPC1 | |
| SCHEMBL8986418 | 0.80 | LMNA (0.61) | LMNASMN1; SMN2HPGDCYP1A2NPC1 | |
| SCHEMBL8986417 | 0.78 | NAMPT (0.65) | LMNAMAPTMAPK1NPC1RAB9A | |
| SCHEMBL27319005 | 0.76 | SLC18A3 (0.47) | LMNAMAPTSLC18A3SMN1; SMN2HPGD | |
| SCHEMBL1996211 | 0.74 | NAMPT (0.57) | LMNAMAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL1996214 | 0.74 | NAMPT (0.57) | LMNAMAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL7565510 | 0.73 | RAB9A (0.71) | LMNAMAPTMAPK1SMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0657440-B1 | Oxazolidine-2-one derivatives as MAO inhibitors | HOFFMANN LA ROCHE (CH) | 2000-04-05 | — | — | EP | disclosed |
| EP-0657440-A1 | Oxazolidine-2-one derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1995-06-14 | — | — | EP | disclosed |