Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.57 |
| ▸ | RAB9A | P51151 | 4/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | USP5 | P45974 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27712494 | 0.80 | NPC1 (0.67) | NPC1RAB9ASMN1; SMN2KMT2ACYP1A2 | |
| SCHEMBL30553026 | 0.79 | SMN1; SMN2 (0.53) | NPC1RAB9ASMN1; SMN2KMT2ACYP1A2 | |
| SCHEMBL122167 | 0.76 | ACVR1 (0.61) | NPC1RAB9ASMN1; SMN2CYP1A2CYP2C9 | |
| SCHEMBL29723028 | 0.76 | ACVR1 (0.61) | NPC1RAB9ASMN1; SMN2CYP1A2CYP2C9 | |
| SCHEMBL3563360 | 0.74 | KMT2A (0.80) | NPC1RAB9ASMN1; SMN2KMT2ACYP1A2 | |
| SCHEMBL1488096 | 0.73 | TDP1 (0.48) | SMN1; SMN2KMT2ACYP1A2LMNAPOLB | |
| SCHEMBL3636921 | 0.73 | RAB9A (0.57) | NPC1RAB9ASMN1; SMN2KMT2APOLB | |
| SCHEMBL9689671 | 0.72 | SMN1; SMN2 (0.56) | RAB9ASMN1; SMN2KMT2ACYP1A2CYP2C9 | |
| SCHEMBL6972582 | 0.72 | KDM4E (0.54) | NPC1RAB9ASMN1; SMN2KMT2ACYP1A2 | |
| SCHEMBL16181504 | 0.72 | KDM4E (0.54) | NPC1RAB9ASMN1; SMN2KMT2ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0572782-B1 | 1-Aryl-3-(3,4-dihydro-4-oxo-3-quinazolinyl)-urea fungicidal agents | AMERICAN CYANAMID CO (US) | 1996-06-26 | — | — | EP | disclosed |
| US-5354755-A | Agricultural uses | AMERICAN CYANAMID COMPANY (US) | 1994-10-11 | — | — | US | disclosed |
| US-5276038-A | 1-aryl-3-(3,4-dihydro-4-oxo-3-quinazolinyl)urea fungicidal agents | AMERICAN CYANAMID COMPANY (US) | 1994-01-04 | — | — | US | disclosed |
| EP-0572782-A1 | 1-Aryl-3-(3,4-dihydro-4-oxo-3-quinazolinyl)-urea fungicidal agents | AMERICAN CYANAMID COMPANY (US) | 1993-12-08 | — | — | EP | disclosed |