Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.80 |
| ▸ | NPC1 | O15118 | 5/20 | 0.74 |
| ▸ | RAB9A | P51151 | 5/20 | 0.74 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.73 |
| ▸ | MEN1 | O00255 | 1/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.67 |
| ▸ | POLB | P06746 | 1/20 | 0.63 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13241783 | 0.81 | KMT2A (0.71) | KMT2ANPC1RAB9AL3MBTL1MEN1 | |
| SCHEMBL7366160 | 0.80 | NPC1 (0.70) | KMT2ANPC1RAB9AL3MBTL1MEN1 | |
| SCHEMBL16554573 | 0.75 | ALOX15 (0.54) | KMT2ANPC1RAB9AL3MBTL1MEN1 | |
| SCHEMBL30553026 | 0.75 | SMN1; SMN2 (0.53) | KMT2ANPC1RAB9AL3MBTL1MEN1 | |
| SCHEMBL8986853 | 0.74 | NPC1 (0.57) | KMT2ANPC1RAB9AL3MBTL1MEN1 | |
| SCHEMBL8986849 | 0.74 | SMN1; SMN2 (0.54) | KMT2ANPC1RAB9AL3MBTL1MEN1 | |
| SCHEMBL8986865 | 0.73 | KMT2A (0.53) | KMT2ANPC1RAB9AL3MBTL1MEN1 | |
| SCHEMBL8986883 | 0.73 | KMT2A (0.70) | KMT2ANPC1RAB9AL3MBTL1MEN1 | |
| SCHEMBL8986858 | 0.73 | SMN1; SMN2 (0.53) | KMT2ANPC1RAB9AL3MBTL1MEN1 | |
| SCHEMBL8986852 | 0.73 | SMN1; SMN2 (0.58) | KMT2ANPC1RAB9AL3MBTL1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7696215-B2 | 4-oxoquinazolin-3-yl benzamide derivatives for the treatment of cytokine diseases | ASTRAZENECA AB (SE) | 2010-04-13 | — | — | US | disclosed |