Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | PRKDC | P78527 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.44 |
| ▸ | TUBB | P07437 | 2/20 | 0.44 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.44 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.44 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.44 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.44 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.44 |
| ▸ | TUBB2A | Q13885 | 2/20 | 0.44 |
| ▸ | TUBB8 | Q3ZCM7 | 2/20 | 0.44 |
| ▸ | TUBA3E | Q6PEY2 | 2/20 | 0.44 |
| ▸ | TUBA1A | Q71U36 | 2/20 | 0.44 |
| ▸ | TUBA1C | Q9BQE3 | 2/20 | 0.44 |
| ▸ | TUBB6 | Q9BUF5 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9054391 | 0.88 | ALDH1A1 (0.43) | CYP3A4ALDH1A1KDM4EMAPTALOX15 | |
| SCHEMBL9348560 | 0.87 | PKM (0.48) | CYP3A4ALDH1A1KDM4EMAPTALOX15 | |
| SCHEMBL8986936 | 0.85 | CHEK1 (0.43) | CYP3A4ALDH1A1KDM4EMAPTALOX15 | |
| SCHEMBL19548283 | 0.84 | HTT (0.50) | CYP3A4ALDH1A1KDM4EMAPTALOX15 | |
| SCHEMBL13000195 | 0.82 | TTR (0.53) | ALDH1A1MAPTALOX15HSD17B10TUBB4A | |
| SCHEMBL9054382 | 0.82 | POLB (0.44) | CYP3A4ALDH1A1KDM4EMAPTALOX15 | |
| SCHEMBL6641000 | 0.81 | ALDH1A1 (0.46) | ALDH1A1KDM4EMAPTTUBB4ATUBB | |
| SCHEMBL9348382 | 0.79 | ALDH1A1 (0.53) | CYP3A4ALDH1A1KDM4EMAPTALOX15 | |
| SCHEMBL18138399 | 0.75 | ALDH1A1 (0.46) | CYP3A4ALDH1A1KDM4EMAPTALOX15 | |
| SCHEMBL10790436 | 0.75 | TUBB4A (0.49) | CYP3A4ALDH1A1KDM4EMAPTALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8188306-B2 | Heat shock protein 90 inhibitors | UNIVERSITY OF KANSAS (US) | 2012-05-29 | — | — | US | disclosed |
| US-8188306-B2 | Heat shock protein 90 inhibitors | UNIVERSITY OF KANSAS (US) | 2012-05-29 | — | — | US | disclosed |
| US-20100099865-A1 | HEAT SHOCK PROTEIN 90 INHIBITORS | UNIVERSITY OF KANSAS (US) | 2010-04-22 | — | — | US | disclosed |
| US-20100099865-A1 | HEAT SHOCK PROTEIN 90 INHIBITORS | UNIVERSITY OF KANSAS (US) | 2010-04-22 | — | — | US | disclosed |
| US-7605288-B2 | Heat shock protein 90 inhibitors | UNIVERSITY OF KANSAS (US) | 2009-10-20 | — | — | US | disclosed |
| US-7605288-B2 | Heat shock protein 90 inhibitors | UNIVERSITY OF KANSAS (US) | 2009-10-20 | — | — | US | disclosed |
| US-20070197787-A1 | Heat shock protein 90 inhibitors | UNIVERSITY OF KANSAS | 2007-08-23 | — | — | US | disclosed |
| US-20070197787-A1 | Heat shock protein 90 inhibitors | UNIVERSITY OF KANSAS | 2007-08-23 | — | — | US | disclosed |
| US-7208630-B2 | Heat shock protein 90 inhibitors | UNIVERSITY OF KANSAS (US) | 2007-04-24 | — | — | US | disclosed |
| US-7208630-B2 | Heat shock protein 90 inhibitors | UNIVERSITY OF KANSAS (US) | 2007-04-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070197787-A1 | Heat shock protein 90 inhibitors | HSP90AB2P, HSP90AB1, HSP90AA1 | CYP3A4 4152/4885ALDH1A1 2042/4885KDM4E 3557/4885 |
| US-20100099865-A1 | HEAT SHOCK PROTEIN 90 INHIBITORS | HSP90AB2P, HSPH1, HSP90AA1 | CYP3A4 4166/4885ALDH1A1 1825/4885KDM4E 3598/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.