Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB1 | Q9H4B7 | 5/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | FYN | P06241 | 1/20 | 0.32 |
| ▸ | XDH | P47989 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 2/20 | 0.32 |
| ▸ | TUBB4A | P04350 | 3/20 | 0.32 |
| ▸ | TUBB | P07437 | 3/20 | 0.32 |
| ▸ | TUBA3C | P0DPH7 | 3/20 | 0.32 |
| ▸ | TUBA1B | P68363 | 3/20 | 0.32 |
| ▸ | TUBA4A | P68366 | 3/20 | 0.32 |
| ▸ | TUBB4B | P68371 | 3/20 | 0.32 |
| ▸ | TUBB3 | Q13509 | 3/20 | 0.32 |
| ▸ | TUBB2A | Q13885 | 3/20 | 0.32 |
| ▸ | TUBB8 | Q3ZCM7 | 3/20 | 0.32 |
| ▸ | TUBA3E | Q6PEY2 | 3/20 | 0.32 |
| ▸ | TUBA1A | Q71U36 | 3/20 | 0.32 |
| ▸ | TUBA1C | Q9BQE3 | 3/20 | 0.32 |
| ▸ | TUBB6 | Q9BUF5 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9053988 | 0.80 | CA2 (0.41) | TUBB1MAPTTUBB4ATUBBTUBA3C | |
| SCHEMBL9578708 | 0.79 | ALOX5 (0.36) | TUBB1MAPTFYNTUBB4ATUBB | |
| SCHEMBL9901198 | 0.73 | PTPN1 (0.37) | PTPN1FYNEGFRTSHRL3MBTL1 | |
| SCHEMBL9578669 | 0.72 | ALOX5 (0.43) | TUBB1MAPTFYNTUBB4ATUBB | |
| SCHEMBL8986945 | 0.71 | TPMT (0.37) | MAPT | |
| SCHEMBL8866713 | 0.71 | ATM (0.50) | MAPTCA2 | |
| SCHEMBL9578759 | 0.70 | ALOX5 (0.33) | PTPN1MAPTIMPDH2IMPDH1 | |
| SCHEMBL10684267 | 0.70 | ADRA1A (0.50) | BACE1 | |
| SCHEMBL8986937 | 0.69 | TNKS2 (0.43) | TUBB1MAPTTUBB4ATUBBTUBA3C | |
| SCHEMBL5782965 | 0.69 | TUBB1 (0.36) | TUBB1PTPN1BACE1MAPTFYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8188306-B2 | Heat shock protein 90 inhibitors | UNIVERSITY OF KANSAS (US) | 2012-05-29 | — | — | US | disclosed |
| US-8188306-B2 | Heat shock protein 90 inhibitors | UNIVERSITY OF KANSAS (US) | 2012-05-29 | — | — | US | disclosed |
| US-20100099865-A1 | HEAT SHOCK PROTEIN 90 INHIBITORS | UNIVERSITY OF KANSAS (US) | 2010-04-22 | — | — | US | disclosed |
| US-20100099865-A1 | HEAT SHOCK PROTEIN 90 INHIBITORS | UNIVERSITY OF KANSAS (US) | 2010-04-22 | — | — | US | disclosed |
| US-7605288-B2 | Heat shock protein 90 inhibitors | UNIVERSITY OF KANSAS (US) | 2009-10-20 | — | — | US | disclosed |
| US-7605288-B2 | Heat shock protein 90 inhibitors | UNIVERSITY OF KANSAS (US) | 2009-10-20 | — | — | US | disclosed |
| US-20070197787-A1 | Heat shock protein 90 inhibitors | UNIVERSITY OF KANSAS | 2007-08-23 | — | — | US | disclosed |
| US-20070197787-A1 | Heat shock protein 90 inhibitors | UNIVERSITY OF KANSAS | 2007-08-23 | — | — | US | disclosed |
| US-7208630-B2 | Heat shock protein 90 inhibitors | UNIVERSITY OF KANSAS (US) | 2007-04-24 | — | — | US | disclosed |
| US-7208630-B2 | Heat shock protein 90 inhibitors | UNIVERSITY OF KANSAS (US) | 2007-04-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070197787-A1 | Heat shock protein 90 inhibitors | HSP90AB2P, HSP90AB1, HSP90AA1 | TUBB1 633/4885PTPN1 4068/4885BACE1 4764/4885 |
| US-20100099865-A1 | HEAT SHOCK PROTEIN 90 INHIBITORS | HSP90AB2P, HSPH1, HSP90AA1 | TUBB1 451/4885PTPN1 4160/4885BACE1 4785/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.