SCHEMBL8987160

SCHEMBL8987160

O=c1cc(-c2ccccc2)cc(-c2ccsc2)[nH]1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2E1 P05181 1/20 0.53
CYP2A6 P11509 1/20 0.53
CYP2B6 P20813 1/20 0.53
GLO1 Q04760 1/20 0.46
TAS2R38 P59533 1/20 0.44
NPY5R Q15761 1/20 0.43
PTPRC P08575 1/20 0.43
CCNB2 O95067 1/20 0.42
CDK1 P06493 1/20 0.42
CCNB1 P14635 1/20 0.42
GSK3B P49841 1/20 0.42
CDK5 Q00535 1/20 0.42
CDK5R1 Q15078 1/20 0.42
CCNB3 Q8WWL7 1/20 0.42
PIK3C3 Q8NEB9 3/20 0.41
NOTUM Q6P988 2/20 0.41
CDK8 P49336 1/20 0.39
SMN1; SMN2 Q16637 2/20 0.39
GPR84 Q9NQS5 1/20 0.37
MAOB P27338 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9522651 0.89 CYP2E1 (0.42) CYP2E1CYP2A6CYP2B6GLO1TAS2R38
SCHEMBL6756097 0.82 TAS2R38 (0.60) TAS2R38PIK3C3NOTUMSMN1; SMN2GPR84
SCHEMBL8799476 0.74 KDM4E (0.44) TAS2R38CCNB2CDK1CCNB1GSK3B
SCHEMBL8987106 0.73 CYP1A2 (0.52) TAS2R38NOTUMSMN1; SMN2GPR84KDM4E
SCHEMBL8987311 0.73 CYP1A2 (0.52) TAS2R38NOTUMSMN1; SMN2GPR84KDM4E
SCHEMBL8987066 0.73 HPGD (0.51) TAS2R38NOTUMSMN1; SMN2GPR84KDM4E
SCHEMBL8799713 0.73 HPGD (0.51) TAS2R38NOTUMSMN1; SMN2GPR84KDM4E
SCHEMBL19955621 0.73 ALDH1A1 (0.52) TAS2R38PIK3C3NOTUMGPR84KDM4E
SCHEMBL6762114 0.73 CTSV (0.51) TAS2R38NOTUMGPR84KDM4EGAA
SCHEMBL8987070 0.73 CTSV (0.51) TAS2R38NOTUMGPR84KDM4EGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5492915-A ANTIINFLAMMATORY AGENTS RHONE-POULENC RORER S.A. (FR) 1996-02-20 US disclosed
US-5366982-A Antiinflammatory agents or antihistamines RHONE-POULENC RORER S.A. (FR) 1994-11-22 US disclosed
EP-0540604-A1 SUBSTITUTED BICYCLIC BIS-ARYL COMPOUNDS EXHIBITING SELECTIVE LEUKOTRIENE B 4? ANTAGONIST ACTIVITY, THEIR PREPARATION AND USE IN PHARMACEUTICAL COMPOSITIONS Aventis Pharma S.A. (FR) 1993-05-12 EP disclosed
WO-1992001675-A2 SUBSTITUTED BICYCLIC BIS-ARYL COMPOUNDS EXHIBITING SELECTIVE LEUKOTRIENE B4 ANTAGONIST ACTIVITY, THEIR PREPARATION AND USE IN PHARMACEUTICAL COMPOSITIONS RHONE-POULENC RORER S.A. (FR) 1992-02-06 WO disclosed