Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 0.62 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.62 |
| ▸ | FEN1 | P39748 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.57 |
| ▸ | NPC1 | O15118 | 4/20 | 0.57 |
| ▸ | MEN1 | O00255 | 3/20 | 0.57 |
| ▸ | RAB9A | P51151 | 3/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | F2R | P25116 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | KDM1A | O60341 | 1/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | CES2 | O00748 | 1/20 | 0.47 |
| ▸ | CES1 | P23141 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20508992 | 0.81 | PTPN1 (0.74) | PTPN1ERCC5FEN1KMT2ANPC1 | |
| SCHEMBL5691811 | 0.80 | PTPN1 (0.72) | PTPN1ERCC5FEN1KMT2ANPC1 | |
| SCHEMBL11197457 | 0.79 | ERCC5 (0.62) | ERCC5FEN1KMT2ANPC1MEN1 | |
| SCHEMBL4363732 | 0.78 | MEN1 (0.89) | KMT2ANPC1MEN1RAB9ATDP1 | |
| SCHEMBL1689206 | 0.77 | EPHX2 (0.68) | KMT2AMEN1POLBSMN1; SMN2HTT | |
| SCHEMBL8987230 | 0.76 | KMT2A (0.63) | KMT2ANPC1MEN1RAB9ATDP1 | |
| SCHEMBL9775157 | 0.76 | PTPN1 (0.57) | PTPN1ERCC5FEN1KMT2ANPC1 | |
| SCHEMBL1098345 | 0.76 | RAB9A (0.77) | PTPN1ERCC5FEN1KMT2ANPC1 | |
| SCHEMBL11572863 | 0.76 | RAB9A (0.71) | KMT2ANPC1MEN1RAB9ATDP1 | |
| SCHEMBL8641263 | 0.76 | NPC1 (0.65) | KMT2ANPC1MEN1RAB9ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5492915-A | ANTIINFLAMMATORY AGENTS | RHONE-POULENC RORER S.A. (FR) | 1996-02-20 | — | — | US | disclosed |
| US-5366982-A | Antiinflammatory agents or antihistamines | RHONE-POULENC RORER S.A. (FR) | 1994-11-22 | — | — | US | disclosed |
| EP-0540604-A1 | SUBSTITUTED BICYCLIC BIS-ARYL COMPOUNDS EXHIBITING SELECTIVE LEUKOTRIENE B 4? ANTAGONIST ACTIVITY, THEIR PREPARATION AND USE IN PHARMACEUTICAL COMPOSITIONS | Aventis Pharma S.A. (FR) | 1993-05-12 | — | — | EP | disclosed |
| WO-1992001675-A2 | SUBSTITUTED BICYCLIC BIS-ARYL COMPOUNDS EXHIBITING SELECTIVE LEUKOTRIENE B4 ANTAGONIST ACTIVITY, THEIR PREPARATION AND USE IN PHARMACEUTICAL COMPOSITIONS | RHONE-POULENC RORER S.A. (FR) | 1992-02-06 | — | — | WO | disclosed |