Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 4/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL308733 | 0.89 | HTT (0.57) | HTTTSHRNLRP3HPGDNPC1 | |
| SCHEMBL30415135 | 0.89 | HTT (0.57) | HTTTSHRNLRP3HPGDNPC1 | |
| SCHEMBL2778140 | 0.84 | HTT (0.56) | HTTTSHRNLRP3HPGDNPC1 | |
| SCHEMBL16487383 | 0.83 | TSHR (0.54) | HTTTSHRNLRP3HPGDALOX5 | |
| SCHEMBL16486722 | 0.83 | TSHR (0.54) | HTTTSHRNLRP3HPGDALOX5 | |
| SCHEMBL2080518 | 0.80 | TSHR (0.51) | HTTTSHRNLRP3HPGDALDH1A1 | |
| SCHEMBL21434178 | 0.77 | LMNA (0.48) | TSHRNPC1ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL6903284 | 0.76 | TSHR (0.58) | HTTTSHRHPGDNPC1ALDH1A1 | |
| SCHEMBL7255678 | 0.75 | HTT (0.62) | HTTTSHRHPGDNPC1ALDH1A1 | |
| SCHEMBL9518458 | 0.74 | HTT (0.57) | HTTTSHRHPGDNPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5543400-A | ANTIBIOTICS | ROUSSEL UCLAF (FR) | 1996-08-06 | — | — | US | disclosed |