Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.59 |
| ▸ | MMP8 | P22894 | 3/20 | 0.53 |
| ▸ | MMP13 | P45452 | 3/20 | 0.53 |
| ▸ | MMP12 | P39900 | 2/20 | 0.53 |
| ▸ | MMP1 | P03956 | 2/20 | 0.53 |
| ▸ | MMP7 | P09237 | 1/20 | 0.53 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.51 |
| ▸ | CA2 | P00918 | 3/20 | 0.48 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ACLY | P53396 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6488752 | 0.83 | IDO1 (0.63) | IDO1MMP8MMP13MMP12MMP1 | |
| SCHEMBL6793104 | 0.79 | IDO1 (0.59) | IDO1MMP8MMP13MMP12MMP1 | |
| SCHEMBL10890460 | 0.79 | IDO1 (0.59) | IDO1MMP8MMP13MMP12MMP1 | |
| SCHEMBL16914880 | 0.79 | MMP8 (0.64) | IDO1MMP8MMP13MMP12MMP1 | |
| SCHEMBL4678467 | 0.78 | CA1 (0.63) | MMP8MMP13MMP1CA2MEN1 | |
| SCHEMBL15754219 | 0.78 | L3MBTL1 (0.64) | IDO1MMP8MMP13MMP12MMP1 | |
| SCHEMBL15622087 | 0.78 | IDO1 (0.68) | IDO1MMP8MMP13MMP12MMP1 | |
| SCHEMBL426660 | 0.76 | IDO1 (0.56) | IDO1MMP8MMP13MMP12MMP1 | |
| SCHEMBL426661 | 0.76 | IDO1 (0.56) | IDO1MMP8MMP13MMP12MMP1 | |
| SCHEMBL3836194 | 0.76 | MMP8 (0.58) | IDO1MMP8MMP13MMP12MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0714303-A1 | CYCLOPENTANE(ENE) HEPTANOIC OR CYCLOPENTANE(ENE) HEPTENOIC ACID, 2-HYDROCARBYL SULFONAMIDOMETHYL AND DERIVATIVES THEREOF AS THERAPEUTIC AGENTS | ALLERGAN, INC. (US) | 1996-06-05 | — | — | EP | disclosed |
| US-5457131-A | Ocular hypotensive agents | ALLERGAN, INC. (US) | 1995-10-10 | — | — | US | disclosed |
| WO-1995005178-A1 | CYCLOPENTANE(ENE) HEPTANOIC OR CYCLOPENTANE(ENE) HEPTENOIC ACID, 2-HYDROCARBYL SULFONAMIDOMETHYL AND DERIVATIVES THEREOF AS THERAPEUTIC AGENTS | ALLERGAN, INC. (US) | 1995-02-23 | — | — | WO | disclosed |
| US-5387608-A | Ocular hypotensive agents for treatment of glaucoma; smooth muscle relaxants | ALLERGAN, INC. (US) | 1995-02-07 | — | — | US | disclosed |