Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | CACNA2D1 | P54289 | 2/20 | 0.47 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.47 |
| ▸ | CACNB1 | Q02641 | 2/20 | 0.47 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.47 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.46 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7335540 | 0.91 | LMNA (0.48) | LMNAGAACYP3A4CYP2C19CYP2C9 | |
| SCHEMBL27463912 | 0.91 | OPRD1 (0.53) | LMNAGAACYP3A4CYP2C19CYP2C9 | |
| SCHEMBL7330964 | 0.88 | CYP3A4 (0.58) | LMNACACNA2D1CACNA1BCACNB1CACNA1C | |
| SCHEMBL7336021 | 0.86 | ACHE (0.60) | LMNACACNA1BCACNA1GGAACYP3A4 | |
| SCHEMBL8989095 | 0.83 | CYP2D6 (0.48) | LMNACACNA2D1CACNA1BCACNB1CACNA1C | |
| SCHEMBL7335379 | 0.83 | DRD4 (0.60) | LMNAGAACYP3A4CYP2C19OPRD1 | |
| Hydrochloric Acid SCHEMBL7326590 | 0.82 | CYP2D6 (0.47) | LMNACACNA2D1CACNA1BCACNB1CACNA1C | |
| SCHEMBL16227069 | 0.77 | KMT2A (0.61) | LMNACYP3A4CYP2C19CYP2C9OPRD1 | |
| SCHEMBL7327529 | 0.76 | SMN1; SMN2 (0.62) | LMNACACNA2D1CACNA1BCACNB1CACNA1C | |
| SCHEMBL7334983 | 0.74 | MEN1 (0.60) | LMNACACNA1BCYP2C19OPRD1OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5545645-A | Heterocyclic derivatives in the treatment of ischaemia and related diseases | SYNTEX PHARMACEUTICALS, LIMITED (GB) | 1996-08-13 | — | — | US | disclosed |
| US-5428037-A | Piperazine derivatives; calcium and sodium channel antagonists | SYNTEX PHARMACEUTICALS, LTD. (GB) | 1995-06-27 | — | — | US | disclosed |