Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.47 |
| ▸ | PTGER1 | P34995 | 4/20 | 0.47 |
| ▸ | THRB | P10828 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | PSEN1 | P49768 | 4/20 | 0.45 |
| ▸ | PSEN2 | P49810 | 4/20 | 0.45 |
| ▸ | APH1B | Q8WW43 | 4/20 | 0.45 |
| ▸ | NCSTN | Q92542 | 4/20 | 0.45 |
| ▸ | APH1A | Q96BI3 | 4/20 | 0.45 |
| ▸ | PSENEN | Q9NZ42 | 4/20 | 0.45 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8989872 | 0.85 | MCOLN3 (0.47) | THRBMEN1KMT2APSEN1PSEN2 | |
| SCHEMBL8989960 | 0.82 | PSEN1 (0.50) | NPSR1THRBMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL8997495 | 0.76 | MCOLN3 (0.53) | MCOLN3ALDH1A1TP53MAPT | |
| SCHEMBL8989955 | 0.72 | PSEN1 (0.44) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8989888 | 0.68 | LMNA (0.60) | MEN1KMT2ATP53MAPT | |
| SCHEMBL6831270 | 0.66 | PSEN1 (0.66) | THRBKMT2APSEN1PSEN2APH1B | |
| SCHEMBL6831344 | 0.65 | PSEN1 (0.61) | THRBPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL6828296 | 0.65 | C5AR1 (0.57) | THRBPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL6555482 | 0.65 | PSEN1 (0.63) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8989962 | 0.64 | PKM (0.58) | KMT2AMCOLN3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5578633-A | VASOPRESSIN AND OXYTOCIN ANTAGONISTS | SANOFI (FR) | 1996-11-26 | — | — | US | disclosed |
| US-5481005-A | N-sulfonylindoline derivatives, their preparation and the pharmaceutical compositions in which they are present | SANOFI (FR) | 1996-01-02 | — | — | US | disclosed |
| US-5397801-A | Affinity for vasopressin and ocytocin receptors; disorders of nervous, cardiovascular and gastrointestinal systems | SANOFI (FR) | 1995-03-14 | — | — | US | disclosed |
| US-5338755-A | Have affinity for vasopressin and ocytocin receptors; intermediates for drugs that act on central nervous system | ELF SANOFI (FR) | 1994-08-16 | — | — | US | disclosed |