Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | CAMK2A | Q9UQM7 | 3/20 | 0.46 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.46 |
| ▸ | KEAP1 | Q14145 | 9/20 | 0.46 |
| ▸ | NFE2L2 | Q16236 | 9/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MMP3 | P08254 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8989960 | 0.79 | PSEN1 (0.50) | MCOLN3KEAP1NFE2L2MAPTTP53 | |
| SCHEMBL8989872 | 0.79 | MCOLN3 (0.47) | MCOLN3 | |
| SCHEMBL8989882 | 0.76 | NPSR1 (0.47) | MCOLN3MAPTTP53ALDH1A1 | |
| SCHEMBL8989962 | 0.73 | PKM (0.58) | MCOLN3PKMKEAP1NFE2L2ALDH1A1 | |
| SCHEMBL8989867 | 0.70 | PKM (0.70) | MCOLN3PKMKEAP1NFE2L2MAPT | |
| SCHEMBL8989846 | 0.70 | MCOLN3 (0.63) | MCOLN3PKMALDH1A1 | |
| SCHEMBL8989952 | 0.70 | MCOLN3 (0.50) | MCOLN3PKMKEAP1NFE2L2MAPT | |
| SCHEMBL8989938 | 0.69 | PKM (0.50) | MCOLN3PKMKEAP1NFE2L2MAPT | |
| SCHEMBL8989902 | 0.69 | MCOLN3 (0.51) | MCOLN3PKMKEAP1NFE2L2MAPT | |
| SCHEMBL8989928 | 0.69 | MMP3 (0.43) | CAMK2ACAMK2GMMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5481005-A | N-sulfonylindoline derivatives, their preparation and the pharmaceutical compositions in which they are present | SANOFI (FR) | 1996-01-02 | — | — | US | disclosed |