Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.61 |
| ▸ | HTT | P42858 | 3/20 | 0.61 |
| ▸ | GAA | P10253 | 2/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | TP53 | P04637 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | NPC1 | O15118 | 1/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.60 |
| ▸ | CCR9 | P51686 | 3/20 | 0.59 |
| ▸ | SQSTM1 | Q13501 | 1/20 | 0.56 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.56 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26619 | 0.88 | LMNA (0.72) | LMNAHTTGAAMEN1ALDH1A1 | |
| SCHEMBL2529943 | 0.87 | CCR9 (0.54) | LMNAHTTCCR9 | |
| SCHEMBL4940505 | 0.85 | CCR9 (0.73) | LMNAHTTCCR9 | |
| SCHEMBL8989887 | 0.85 | LMNA (0.77) | LMNAHTTALDH1A1TP53MAPT | |
| SCHEMBL28643 | 0.82 | CCR9 (0.74) | LMNAHTTGAAMEN1ALDH1A1 | |
| SCHEMBL8989935 | 0.82 | LMNA (0.56) | LMNAHTTTP53MAPTKMT2A | |
| SCHEMBL29013 | 0.80 | LMNA (0.70) | LMNAHTTALDH1A1TP53MAPT | |
| SCHEMBL28248 | 0.80 | LMNA (0.70) | LMNAHTTALDH1A1TP53MAPT | |
| SCHEMBL2536261 | 0.80 | ALDH1A1 (0.62) | LMNAHTTGAAALDH1A1TP53 | |
| SCHEMBL27476 | 0.80 | CRHBP (0.57) | LMNAHTTTP53MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5578633-A | VASOPRESSIN AND OXYTOCIN ANTAGONISTS | SANOFI (FR) | 1996-11-26 | — | — | US | disclosed |
| US-5481005-A | N-sulfonylindoline derivatives, their preparation and the pharmaceutical compositions in which they are present | SANOFI (FR) | 1996-01-02 | — | — | US | disclosed |
| US-5397801-A | Affinity for vasopressin and ocytocin receptors; disorders of nervous, cardiovascular and gastrointestinal systems | SANOFI (FR) | 1995-03-14 | — | — | US | disclosed |
| US-5338755-A | Have affinity for vasopressin and ocytocin receptors; intermediates for drugs that act on central nervous system | ELF SANOFI (FR) | 1994-08-16 | — | — | US | disclosed |