Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | MMP8 | P22894 | 2/20 | 0.44 |
| ▸ | ANPEP | P15144 | 2/20 | 0.44 |
| ▸ | ERAP1 | Q9NZ08 | 2/20 | 0.44 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | ALPI | P09923 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | XIAP | P98170 | 1/20 | 0.41 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11836988 | 0.91 | MMP12 (0.50) | TSHRHTTGAAPTGS1 | |
| SCHEMBL18424616 | 0.86 | ALDH1A1 (0.48) | ALDH1A1TSHRMMP8ANPEPERAP1 | |
| SCHEMBL6695161 | 0.86 | ALDH1A1 (0.55) | ALDH1A1TSHRMMP8ANPEPERAP1 | |
| SCHEMBL2569812 | 0.84 | ALDH1A1 (0.53) | ALDH1A1TSHRMMP8ANPEPERAP1 | |
| SCHEMBL7098213 | 0.81 | ALDH1A1 (0.50) | ALDH1A1TSHRMMP8KMT2AMEN1 | |
| SCHEMBL7098205 | 0.81 | ALDH1A1 (0.50) | ALDH1A1TSHRMMP8KMT2AMEN1 | |
| SCHEMBL341788 | 0.78 | ANPEP (0.52) | TSHRMMP8ANPEPERAP1ERAP2 | |
| SCHEMBL9264377 | 0.77 | ANPEP (0.50) | TSHRMMP8ANPEPERAP1ERAP2 | |
| SCHEMBL8534054 | 0.77 | MMP8 (0.50) | TSHRMMP8ANPEPERAP1ERAP2 | |
| SCHEMBL28105208 | 0.77 | GRIK1 (0.49) | ALDH1A1KMT2ASMN1; SMN2MAPTPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5563250-A | Cleavable conjugates for the delivery and release of agents in native form | NEORX CORPORATION (US) | 1996-10-08 | — | — | US | disclosed |
| US-5141648-A | Methods for isolating compounds using cleavable linker bound matrices | NEORX CORPORATION (US) | 1992-08-25 | — | — | US | disclosed |
| EP-0318948-B1 | CLEAVABLE IMMUNOCONJUGATES FOR THE DELIVERY AND RELEASE OF AGENTS IN NATIVE FORM | NEORX CORPORATION (US) | 1992-08-19 | — | — | EP | disclosed |
| US-5017693-A | Methods for introducing a sulfhydryl amino or hydroxyl groups to a compound | NEORX CORPORATION (US) | 1991-05-21 | — | — | US | disclosed |
| EP-0318948-A2 | Cleavable immunoconjugates for the delivery and release of agents in native form | NEORX CORPORATION (US) | 1989-06-07 | — | — | EP | disclosed |