Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 5/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.45 |
| ▸ | ADORA1 | P30542 | 5/20 | 0.45 |
| ▸ | ADORA2B | P29275 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | POLB | P06746 | 4/20 | 0.40 |
| ▸ | HPGD | P15428 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.40 |
| ▸ | PTPN7 | P35236 | 2/20 | 0.40 |
| ▸ | RECQL | P46063 | 2/20 | 0.40 |
| ▸ | BLM | P54132 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | SAE1 | Q9UBE0 | 2/20 | 0.40 |
| ▸ | UBA2 | Q9UBT2 | 2/20 | 0.40 |
| ▸ | GAPDH | P04406 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8990692 | 0.80 | HPGD (0.47) | ALDH1A1HSD17B10KMT2APOLBHPGD | |
| SCHEMBL6946402 | 0.73 | ALDH1A1 (0.41) | ADORA3ADORA2AADORA1ADORA2BALDH1A1 | |
| SCHEMBL27405338 | 0.73 | POLB (0.47) | ADORA3ADORA2AADORA1ADORA2BALDH1A1 | |
| SCHEMBL8990541 | 0.71 | ADORA2A (0.50) | ADORA3ADORA2AADORA1ADORA2BALDH1A1 | |
| SCHEMBL3268905 | 0.70 | ALDH1A1 (0.40) | ADORA3ADORA2AADORA1ADORA2BALDH1A1 | |
| SCHEMBL8990766 | 0.69 | ADORA2A (0.41) | ADORA3ADORA2AADORA1ADORA2BALDH1A1 | |
| SCHEMBL8990654 | 0.69 | ALDH1A1 (0.45) | ADORA3ADORA2AADORA1ADORA2BALDH1A1 | |
| SCHEMBL8494359 | 0.69 | ALDH1A1 (0.63) | ADORA3ADORA2AADORA1ADORA2BALDH1A1 | |
| SCHEMBL25138717 | 0.67 | ALDH1A1 (0.46) | ADORA3ADORA2AADORA1ADORA2BALDH1A1 | |
| SCHEMBL8990583 | 0.67 | ADORA2A (0.53) | ADORA3ADORA2AADORA1ADORA2BALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5500428-A | Furyl-substituted purines and adenosine antagonists | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1996-03-19 | — | — | US | disclosed |
| US-5300509-A | Adenosine antagonists for treating cardiovascular disorders, vasodilation | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1994-04-05 | — | — | US | disclosed |