Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 10/20 | 0.47 |
| ▸ | MAPT | P10636 | 7/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.47 |
| ▸ | MEN1 | O00255 | 5/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 3/20 | 0.47 |
| ▸ | USP2 | O75604 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | CASP7 | P55210 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | RECQL | P46063 | 2/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.47 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.47 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8990531 | 0.80 | ADORA3 (0.45) | HPGDMAPTALDH1A1KMT2AHSD17B10 | |
| SCHEMBL8990654 | 0.75 | ALDH1A1 (0.45) | HPGDMAPTALDH1A1KMT2AHSD17B10 | |
| SCHEMBL7402584 | 0.68 | MEN1 (0.64) | HPGDMAPTALDH1A1KMT2AHSD17B10 | |
| SCHEMBL7149150 | 0.68 | HPGD (0.53) | HPGDMAPTALDH1A1KMT2AHSD17B10 | |
| SCHEMBL8990541 | 0.66 | ADORA2A (0.50) | HPGDMAPTALDH1A1KMT2AHSD17B10 | |
| SCHEMBL8990766 | 0.66 | ADORA2A (0.41) | HPGDMAPTALDH1A1KMT2AHSD17B10 | |
| SCHEMBL5036755 | 0.65 | ALDH1A1 (0.54) | HPGDMAPTALDH1A1KMT2AHSD17B10 | |
| SCHEMBL2113647 | 0.64 | ALDH1A1 (1.00) | HPGDMAPTALDH1A1KMT2AHSD17B10 | |
| SCHEMBL9328262 | 0.64 | ADORA3 (0.67) | ALDH1A1HSD17B10MAPK1SMN1; SMN2 | |
| SCHEMBL7146168 | 0.64 | ALDH1A1 (0.60) | HPGDMAPTALDH1A1KMT2AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5500428-A | Furyl-substituted purines and adenosine antagonists | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1996-03-19 | — | — | US | disclosed |
| US-5300509-A | Adenosine antagonists for treating cardiovascular disorders, vasodilation | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1994-04-05 | — | — | US | disclosed |
| EP-0544445-A2 | Furyl-substituted purines, oxazolopyrimidines and pteridines as adenosine antagonists | ZENECA LIMITED (GB) | 1993-06-02 | — | — | EP | disclosed |