Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | IDH1 | O75874 | 2/20 | 0.37 |
| ▸ | KLK7 | P49862 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8990539 | 0.79 | MAPT (0.58) | SMN1; SMN2MEN1KMT2AMAPK1TP53 | |
| SCHEMBL660601 | 0.72 | KDM4E (0.53) | SMN1; SMN2MAPK1ADORA2AKDM4EALDH1A1 | |
| SCHEMBL8990632 | 0.69 | MAPT (0.57) | ADORA2AKDM4EALDH1A1HPGDGAA | |
| SCHEMBL8990784 | 0.67 | ADORA2A (0.69) | SMN1; SMN2MEN1KMT2AMAPK1TP53 | |
| SCHEMBL8990698 | 0.67 | ALDH1A1 (0.48) | SMN1; SMN2KMT2ATP53ALDH1A1GAA | |
| SCHEMBL10361521 | 0.60 | CA1 (0.44) | SMN1; SMN2MEN1KMT2AADORA2AHPGD | |
| SCHEMBL8990616 | 0.60 | MAPT (0.43) | SMN1; SMN2MEN1KMT2AMAPK1TP53 | |
| SCHEMBL10361087 | 0.60 | ALDH1A1 (0.39) | ALDH1A1GAALMNAMAPT | |
| SCHEMBL4898808 | 0.60 | CA1 (0.55) | SMN1; SMN2MEN1KMT2ATP53KDM4E | |
| SCHEMBL28120909 | 0.59 | IDH1 (0.49) | SMN1; SMN2MAPK1TP53HPGDIDH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5500428-A | Furyl-substituted purines and adenosine antagonists | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1996-03-19 | — | — | US | disclosed |
| US-5300509-A | Adenosine antagonists for treating cardiovascular disorders, vasodilation | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1994-04-05 | — | — | US | disclosed |
| EP-0544445-A2 | Furyl-substituted purines, oxazolopyrimidines and pteridines as adenosine antagonists | ZENECA LIMITED (GB) | 1993-06-02 | — | — | EP | disclosed |