Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 12/20 | 0.43 |
| ▸ | TP53 | P04637 | 6/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8990571 | 0.88 | ADK (0.44) | MAPTTP53SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL14486566 | 0.71 | ALDH1A1 (0.41) | MAPTTP53SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL8990632 | 0.68 | MAPT (0.57) | MAPTALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL1219378 | 0.68 | SIRT1 (0.44) | MAPTTP53SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL8990539 | 0.66 | MAPT (0.58) | MAPTTP53SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL8990861 | 0.66 | KDM4E (0.43) | MAPTRAB9ANPC1ALDH1A1KDM4E | |
| SCHEMBL1831744 | 0.62 | L3MBTL1 (0.42) | MAPTRAB9ANPC1ALDH1A1KDM4E | |
| SCHEMBL1831711 | 0.62 | ERCC1 (0.38) | MAPTRAB9ANPC1POLBL3MBTL1 | |
| SCHEMBL1828867 | 0.62 | ALDH1A1 (0.46) | MAPTTP53SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL8893596 | 0.62 | POLB (0.51) | MAPTALDH1A1KDM4EHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5500428-A | Furyl-substituted purines and adenosine antagonists | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1996-03-19 | — | — | US | disclosed |
| US-5300509-A | Adenosine antagonists for treating cardiovascular disorders, vasodilation | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1994-04-05 | — | — | US | disclosed |
| EP-0544445-A2 | Furyl-substituted purines, oxazolopyrimidines and pteridines as adenosine antagonists | ZENECA LIMITED (GB) | 1993-06-02 | — | — | EP | disclosed |