Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.55 |
| ▸ | CA2 | P00918 | 1/20 | 0.55 |
| ▸ | ACHE | P22303 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | KDM1A | O60341 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | PPARD | Q03181 | 1/20 | 0.44 |
| ▸ | PPARA | Q07869 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15325816 | 0.88 | ALDH1A1 (0.61) | CA1CA2ACHEALDH1A1MAPT | |
| SCHEMBL1966606 | 0.81 | SMN1; SMN2 (0.49) | CA1CA2ACHEALDH1A1MAPT | |
| SCHEMBL178554 | 0.79 | ACHE (0.60) | CA1CA2ACHEALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL5774500 | 0.79 | ACHE (0.60) | CA1CA2ACHEALDH1A1MAPT | |
| SCHEMBL3131362 | 0.79 | KDM4E (0.60) | ALDH1A1MAPTLMNATP53KMT2A | |
| SCHEMBL9781293 | 0.78 | ACHE (0.58) | CA1CA2ACHEALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL3657271 | 0.78 | ACHE (0.58) | CA1CA2ACHEALDH1A1MAPT | |
| SCHEMBL5954637 | 0.78 | ACHE (0.58) | CA1CA2ACHEALDH1A1MAPT | |
| SCHEMBL12870325 | 0.78 | ACHE (0.58) | CA1CA2ACHEALDH1A1MAPT | |
| SCHEMBL2438051 | 0.76 | MAPT (0.53) | CA1CA2ACHEALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080249180-A1 | MALONAMIDES AS OREXIN ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-10-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080249180-A1 | MALONAMIDES AS OREXIN ANTAGONISTS | HCRTR2, HCRTR1, MTNR1B | CA1 1057/4885CA2 930/4885ACHE 3011/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.