Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPBWR1 | P48145 | 10/20 | 0.56 |
| ▸ | DGAT1 | O75907 | 5/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.53 |
| ▸ | CBFB | Q13951 | 1/20 | 0.51 |
| ▸ | AMY1A | P0DUB6 | 3/20 | 0.50 |
| ▸ | SOAT1 | P35610 | 2/20 | 0.49 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.46 |
| ▸ | FLT3 | P36888 | 1/20 | 0.46 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15231839 | 0.90 | NPBWR1 (0.43) | NPBWR1DGAT1KCNH2CBFBAMY1A | |
| SCHEMBL900794 | 0.81 | NPBWR1 (0.74) | NPBWR1DGAT1KCNH2CBFBSOAT1 | |
| SCHEMBL2898110 | 0.79 | NPC1 (0.67) | AMY1AFGFR1 | |
| SCHEMBL18229694 | 0.77 | HDAC6 (0.66) | — | |
| SCHEMBL27040014 | 0.77 | NPBWR1 (0.72) | NPBWR1DGAT1KCNH2CBFBSOAT1 | |
| SCHEMBL31593060 | 0.77 | NPBWR1 (0.72) | NPBWR1DGAT1KCNH2CBFBSOAT1 | |
| SCHEMBL4176876 | 0.77 | CBFB (0.71) | NPBWR1DGAT1KCNH2CBFBSOAT1 | |
| SCHEMBL10325798 | 0.76 | NPBWR1 (0.64) | NPBWR1DGAT1KCNH2CBFBSOAT1 | |
| SCHEMBL26597176 | 0.76 | ALDH1A1 (0.67) | AMY1A | |
| SCHEMBL14074150 | 0.76 | DYRK1A (0.57) | NPBWR1DGAT1KCNH2CBFBSOAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013130370-A2 | COMPOUNDS AS DGAT-1 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2013-09-06 | — | — | WO | disclosed |
| WO-2013130370-A2 | COMPOUNDS AS DGAT-1 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2013-09-06 | — | — | WO | disclosed |
| WO-2012096813-A1 | IMIDAZOLE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2012-07-19 | — | — | WO | disclosed |
| WO-2012044567-A2 | IMIDAZOLE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2012-04-05 | — | — | WO | disclosed |