Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GHSR | Q92847 | 2/20 | 0.42 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.42 |
| ▸ | TACR1 | P25103 | 1/20 | 0.37 |
| ▸ | CCR3 | P51677 | 9/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 2/20 | 0.34 |
| ▸ | CNR1 | P21554 | 2/20 | 0.34 |
| ▸ | CNR2 | P34972 | 2/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.34 |
| ▸ | ABHD12 | Q8N2K0 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8991023 | 1.00 | GHSR (0.42) | GHSRAGTR1TACR1CCR3CYP2D6 | |
| SCHEMBL8990818 | 0.92 | GHSR (0.47) | GHSRAGTR1TACR1OPRM1HDAC1 | |
| SCHEMBL8990812 | 0.92 | GHSR (0.47) | GHSRAGTR1TACR1OPRM1HDAC1 | |
| SCHEMBL8991114 | 0.90 | AGTR1 (0.41) | GHSRAGTR1TACR1 | |
| SCHEMBL8991117 | 0.90 | AGTR1 (0.41) | GHSRAGTR1TACR1 | |
| SCHEMBL8991024 | 0.88 | GHSR (0.51) | GHSRAGTR1TACR1OPRM1OPRK1 | |
| SCHEMBL8990994 | 0.85 | GHSR (0.42) | GHSRAGTR1TACR1OPRM1OPRK1 | |
| SCHEMBL8990867 | 0.83 | CCR3 (0.34) | AGTR1TACR1CCR3CYP2D6FAAH | |
| SCHEMBL8990829 | 0.83 | GHSR (0.52) | GHSRAGTR1TACR1OPRM1OPRK1 | |
| SCHEMBL8990748 | 0.83 | GHSR (0.50) | GHSRAGTR1TACR1OPRM1HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5545735-A | ANIMAL GROWTH REGULATORS | MERCK & CO., INC. (US) | 1996-08-13 | — | — | US | claimed |
| WO-1995009633-A1 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO., INC. (US) | 1995-04-13 | — | — | WO | claimed |
| US-5545735-A | ANIMAL GROWTH REGULATORS | MERCK & CO., INC. (US) | 1996-08-13 | — | — | US | disclosed |
| WO-1995009633-A1 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO., INC. (US) | 1995-04-13 | — | — | WO | disclosed |