Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 2/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | HPGD | P15428 | 4/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | BPTF | Q12830 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
| ▸ | OGA | O60502 | 1/20 | 0.33 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.33 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8917193 | 0.75 | MCHR1 (0.48) | MCHR1HDAC6ALDH1A1HPGDTP53 | |
| SCHEMBL8918612 | 0.75 | HTR1A (0.40) | MCHR1NOTUMHDAC6ALDH1A1HPGD | |
| SCHEMBL8917714 | 0.72 | MCHR1 (0.55) | MCHR1HDAC6ALDH1A1HPGDTP53 | |
| SCHEMBL8917039 | 0.70 | NOTUM (0.50) | MCHR1NOTUMHDAC6ALDH1A1HPGD | |
| SCHEMBL8917620 | 0.70 | NOTUM (0.46) | NOTUMKDRBPTFGRM5KCNQ2 | |
| SCHEMBL8918025 | 0.67 | HTR1A (0.43) | MCHR1NOTUMHDAC6ALDH1A1TP53 | |
| SCHEMBL27108590 | 0.65 | NR1H2 (0.52) | HDAC6MAPK1KDM4EMAPT | |
| SCHEMBL12810891 | 0.65 | HDAC6 (0.40) | HDAC6ALDH1A1HPGDTP53USP2 | |
| SCHEMBL11343266 | 0.65 | MCHR1 (0.56) | MCHR1NOTUMBAZ2BRIPK1HRH3 | |
| SCHEMBL25797048 | 0.65 | ATM (0.42) | HDAC6ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5532240-A | ANTIPSYCHOTIC AGENTS AND ANTISEROTONIN AGENTS | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1996-07-02 | — | — | US | disclosed |
| EP-0596125-A1 | CONDENSED THIOPHENE COMPOUND AND PHARMACEUTICAL USE THEREOF | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1994-05-11 | — | — | EP | disclosed |