Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 3/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.47 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.44 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.43 |
| ▸ | BPTF | Q12830 | 1/20 | 0.43 |
| ▸ | GRM5 | P41594 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | PNMT | P11086 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26076488 | 0.82 | MAPK1 (0.50) | HDAC6KCNQ2MAPTHPGDMEN1 | |
| SCHEMBL13985847 | 0.82 | HDAC6 (0.41) | NOTUMHDAC6KCNQ2MCHR1HRH3 | |
| SCHEMBL13985779 | 0.80 | ESR2 (0.55) | HDAC6KCNQ2KDM4EMAPT | |
| SCHEMBL10648892 | 0.78 | NOTUM (0.44) | NOTUMHDAC6MCHR1BPTFGRM5 | |
| SCHEMBL8916750 | 0.77 | NOTUM (0.43) | NOTUMHDAC6MCHR1BPTFGRM5 | |
| SCHEMBL8918025 | 0.77 | HTR1A (0.43) | NOTUMHDAC6MCHR1BPTFGRM5 | |
| SCHEMBL8054291 | 0.74 | MAOA (0.44) | KCNQ2PNMT | |
| SCHEMBL26076553 | 0.74 | EGFR (0.39) | HDAC6KCNQ2HRH3MAPTHPGD | |
| SCHEMBL13560073 | 0.74 | ALDH1A1 (0.43) | GRM5ALDH1A1L3MBTL1KDM4EMAPT | |
| SCHEMBL10649424 | 0.73 | NOTUM (0.57) | NOTUMKCNQ2BPTFGRM5HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5691330-A | ANTIPSYCHOTIC AGENT | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1997-11-25 | — | — | US | disclosed |
| US-5532240-A | ANTIPSYCHOTIC AGENTS AND ANTISEROTONIN AGENTS | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1996-07-02 | — | — | US | disclosed |
| EP-0596125-A1 | CONDENSED THIOPHENE COMPOUND AND PHARMACEUTICAL USE THEREOF | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1994-05-11 | — | — | EP | disclosed |