SCHEMBL8992273

SCHEMBL8992273

CC(C)[SiH](C)c1ccccc1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 2/20 0.35
F2 P00734 1/20 0.33
TAAR1 Q96RJ0 6/20 0.32
SLC6A2 P23975 2/20 0.32
MAOA P21397 1/20 0.32
SLC6A4 P31645 1/20 0.32
SLC6A3 Q01959 1/20 0.32
SIGMAR1 Q99720 1/20 0.32
CYP2A6 P11509 1/20 0.32
ADORA2A P29274 1/20 0.32
ADORA1 P30542 1/20 0.32
LMNA P02545 3/20 0.32
TSHR P16473 2/20 0.32
ALOX12 P18054 2/20 0.32
ACHE P22303 1/20 0.32
ADRA2A P08913 1/20 0.31
ADRA2C P18825 1/20 0.31
CYP2D6 P10635 1/20 0.31
HIF1A Q16665 1/20 0.31
KDM4E B2RXH2 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23701142 0.79 ALDH1A1 (0.41) LMNATSHRALOX12ADRA2AADRA2C
SCHEMBL19890844 0.79 ALDH1A1 (0.41) LMNATSHRALOX12ADRA2AADRA2C
SCHEMBL5613374 0.76 F2 (0.32) TDP1F2LMNATSHRALOX12
SCHEMBL27955651 0.76 TSHR (0.38) F2LMNATSHRALOX12ACHE
SCHEMBL27627719 0.76 F2 (0.32) F2LMNATSHRALOX12ACHE
SCHEMBL1325645 0.74 TDP1 (0.36) TDP1TAAR1SLC6A2MAOASLC6A4
SCHEMBL380702 0.74 TDP1 (0.36) TDP1TAAR1SLC6A2MAOASLC6A4
SCHEMBL4226112 0.74 TDP1 (0.32) TDP1TAAR1SLC6A2MAOASLC6A4
SCHEMBL4230911 0.74 TDP1 (0.32) TDP1TAAR1SLC6A2MAOASLC6A4
Fluoride SCHEMBL27639901 0.72 TDP1 (0.35) TDP1TAAR1SLC6A2MAOASLC6A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5516871-A Diphenylsiloxane oligomers functionalized at both terminals and methods for the preparation thereof DOW CORNING ASIA, LTD. (JP) 1996-05-14 US claimed
US-5502229-A ENDCAPPING DOW CORNING ASIA, LTD. (JP) 1996-03-26 US claimed
CN-113413916-B Silicon-based substituted triphenyl phosphite coordination platinum catalyst, preparation method thereof and organic silicon impregnating varnish 杭州师范大学 2022-05-27 CN disclosed
CN-113413916-A Silicon-based substituted triphenyl phosphite coordination platinum catalyst, preparation method thereof and organic silicon impregnating varnish 杭州师范大学 2021-09-21 CN disclosed
US-5516871-A Diphenylsiloxane oligomers functionalized at both terminals and methods for the preparation thereof DOW CORNING ASIA, LTD. (JP) 1996-05-14 US disclosed
US-5502229-A ENDCAPPING DOW CORNING ASIA, LTD. (JP) 1996-03-26 US disclosed