SCHEMBL8992349

SCHEMBL8992349

Cc1ccc(C2(c3ccc(C)cc3)CC=CC2=O)cc1

nearest known ligand 0.34

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 4/20 0.34
MAOA P21397 2/20 0.34
SLC6A2 P23975 1/20 0.33
SLC6A4 P31645 1/20 0.33
SLC6A3 Q01959 1/20 0.33
KCNH2 Q12809 1/20 0.33
MGLL Q99685 1/20 0.32
ACHE P22303 2/20 0.32
TDP1 Q9NUW8 1/20 0.32
CA1 P00915 1/20 0.32
CA2 P00918 1/20 0.32
OPRM1 P35372 1/20 0.31
OPRK1 P41145 1/20 0.31
OPRL1 P41146 1/20 0.31
PIM1 P11309 1/20 0.31
HPGD P15428 1/20 0.31
PIM2 Q9P1W9 1/20 0.31
HSD17B10 Q99714 1/20 0.30
F2 P00734 1/20 0.30
ELANE P08246 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL577190 0.67 MAOB (0.36) MAOBMAOASLC6A2SLC6A4SLC6A3
SCHEMBL6205000 0.61
SCHEMBL12920578 0.61 MAOB (0.39) MAOBMAOASLC6A2SLC6A4SLC6A3
SCHEMBL24570960 0.60 MAOB (0.35) MAOBMAOAACHE
SCHEMBL5790701 0.60 HDAC4 (0.47) OPRM1MAPT
P-Xylene SCHEMBL28011603 0.59 ACHE (0.57) MAOBMAOAMGLLACHETDP1
SCHEMBL8117721 0.58 MAOB (0.36) MAOBMAOASLC6A2SLC6A4SLC6A3
SCHEMBL12920581 0.58 MEN1 (0.63) MAOBMAOASLC6A2SLC6A4SLC6A3
SCHEMBL8351738 0.58 OPRM1 (0.67) MAOBMAOAOPRM1OPRK1OPRL1
P-Xylene SCHEMBL28336749 0.57 ACHE (0.80) ACHETDP1CA1CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0445749-B1 N-Monosubstituted cyclopentenylamines, a process for their preparation and their use as medicaments FUJISAWA PHARMACEUTICAL CO (JP) 1996-07-10 EP disclosed
US-5256824-A Anticholinergic agents FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1993-10-26 US disclosed
EP-0445749-A1 N-Monosubstituted cyclopentenylamines, a process for their preparation and their use as medicaments FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1991-09-11 EP disclosed