Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.47 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6815544 | 0.87 | LMNA (0.57) | MAPTNPC1RAB9ASMPD1HDAC1 | |
| SCHEMBL6815303 | 0.84 | LMNA (0.58) | NPC1RAB9ACA1CA2LOXL2 | |
| SCHEMBL4001117 | 0.83 | LMNA (0.52) | MAPTNPC1RAB9ASMPD1HDAC1 | |
| SCHEMBL27168760 | 0.82 | LOXL2 (0.51) | NPC1RAB9ACA1CA2LOXL2 | |
| SCHEMBL8993158 | 0.82 | HSP90AA1 (0.49) | NPC1RAB9ACA1CA2LOXL2 | |
| SCHEMBL16143289 | 0.82 | HPGD (0.52) | MAPTNPC1RAB9ACA1CA2 | |
| SCHEMBL6392561 | 0.81 | NPC1 (0.70) | NPC1RAB9AHDAC1HDAC8HDAC6 | |
| SCHEMBL1458108 | 0.81 | LOXL2 (0.57) | MAPTHIF1ANPC1RAB9ALOXL2 | |
| SCHEMBL8429886 | 0.81 | MAPT (0.60) | MAPTHIF1ACA1CA2HDAC6 | |
| SCHEMBL6825689 | 0.81 | CA1 (0.56) | MAPTHIF1ANPC1RAB9ACA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5516777-A | PROSTATE CANCER THERAPY | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1996-05-14 | — | — | US | disclosed |
| US-5409928-A | Prostate diseases, alopecia | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1995-04-25 | — | — | US | disclosed |
| EP-0594149-A2 | Condensed pyrazole derivatives, method of manufacturing the same, and androgen inhibitor | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1994-04-27 | — | — | EP | disclosed |