Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 2/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.33 |
| ▸ | CFB | P00751 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7043892 | 0.90 | ADRA2A (0.41) | ADRA2AADRA2BADRA2CADRA1ATAAR1 | |
| SCHEMBL7046475 | 0.89 | ADRA2A (0.44) | ADRA2AADRA2BADRA2CADRA1ATAAR1 | |
| SCHEMBL7047719 | 0.82 | ADRA1A (0.39) | ADRA2AADRA2BADRA2CADRA1ATAAR1 | |
| SCHEMBL7048861 | 0.78 | ADRA2A (0.46) | ADRA2AADRA2BADRA2CADRA1ATAAR1 | |
| SCHEMBL7046794 | 0.77 | TRPV1 (0.46) | ADRA2AADRA2BADRA2CADRA1ATAAR1 | |
| SCHEMBL7047687 | 0.75 | ADRA2A (0.47) | ADRA2AADRA2BADRA2CADRA1ATAAR1 | |
| SCHEMBL7042987 | 0.73 | ADRA2A (0.46) | ADRA2AADRA2BADRA2CADRA1ATAAR1 | |
| SCHEMBL7043711 | 0.69 | ADRA2A (0.41) | ADRA2AADRA2BADRA2CADRA1ATAAR1 | |
| SCHEMBL9006740 | 0.69 | ADRA2A (0.46) | ADRA2AADRA2BADRA2CADRA1ATAAR1 | |
| SCHEMBL7047984 | 0.67 | ADRA2A (0.49) | ADRA2AADRA2BADRA2CADRA1ATAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0724439-A1 | USE OF 2-(2-ALKYLPHENYLAMINO)-OXAZOLINES, -THIAZOLINES AND -IMIDAZOLINES AS ALPHA 2 ADRENERGIC AGENTS | Allergan (US) | 1996-08-07 | — | — | EP | disclosed |
| WO-1995011021-A1 | USE OF 2-(2-ALKYLPHENYLAMINO)-OXAZOLINES, -THIAZOLINES AND -IMIDAZOLINES AS ALPHA 2 ADRENERGIC AGENTS | ALLERGAN (US) | 1995-04-27 | — | — | WO | disclosed |