Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 17/20 | 0.74 |
| ▸ | PTGS1 | P23219 | 8/20 | 0.69 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.51 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8993325 | 0.87 | PTGS2 (0.76) | PTGS2PTGS1 | |
| SCHEMBL8651364 | 0.85 | PTGS2 (1.00) | PTGS2PTGS1 | |
| SCHEMBL8993420 | 0.84 | PTGS2 (0.71) | PTGS2PTGS1 | |
| SCHEMBL5048802 | 0.82 | AHR (0.52) | PTGS2PTGS1 | |
| SCHEMBL8652581 | 0.82 | PTGS2 (1.00) | PTGS2PTGS1 | |
| SCHEMBL7865484 | 0.78 | PTGS2 (0.71) | PTGS2PTGS1 | |
| SCHEMBL6251471 | 0.76 | PTGS2 (0.72) | PTGS2PTGS1SLC6A3 | |
| SCHEMBL13601374 | 0.75 | MAPK1 (0.48) | — | |
| SCHEMBL8993482 | 0.74 | PTGS2 (0.77) | PTGS2PTGS1 | |
| SCHEMBL8655189 | 0.73 | PTGS2 (0.78) | PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0724566-A1 | 1,2-DIARYLCYCLOPENTENYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-08-07 | — | — | EP | disclosed |
| WO-1995011883-A1 | 1,2-DIARYLCYCLOPENTENYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1995-05-04 | — | — | WO | disclosed |