Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 19/20 | 0.71 |
| ▸ | PTGS1 | P23219 | 5/20 | 0.71 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8653009 | 0.87 | PTGS2 (0.66) | PTGS2PTGS1MAPK14 | |
| SCHEMBL8993369 | 0.86 | PTGS2 (0.60) | PTGS2PTGS1 | |
| SCHEMBL12570643 | 0.84 | PTGS2 (0.58) | PTGS2PTGS1 | |
| SCHEMBL8993420 | 0.83 | PTGS2 (0.71) | PTGS2PTGS1 | |
| Sc-57666 SCHEMBL213008 | 0.83 | PTGS2 (1.00) | PTGS2PTGS1 | |
| Fluoresone SCHEMBL24999 | 0.82 | PSIP1 (0.58) | PTGS2 | |
| SCHEMBL8993325 | 0.81 | PTGS2 (0.76) | PTGS2PTGS1 | |
| SCHEMBL6251471 | 0.81 | PTGS2 (0.72) | PTGS2PTGS1 | |
| SCHEMBL214185 | 0.79 | PTGS2 (1.00) | PTGS2PTGS1 | |
| SCHEMBL8993482 | 0.79 | PTGS2 (0.77) | PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140179-A2 | USE OF A CYCLOOXYGENASE 2 INHIBITOR AND AN INTEGRIN ANTAGONIST AS A COMBINATION THERAPY IN THE TREATMENT OF NEOPLASIA | G.D. SEARLE & CO. (US) | 2001-10-10 | — | — | EP | claimed |
| WO-2000038786-A2 | USE OF CYCLOOXYGENASE 2 INHIBITOR AND AN INTEGRIN ANTAGONIST AS A COMBINATION THERAPY IN THE TREATMENT OF NEOPLASIA | G.D. SEARLE & CO. (US) | 2000-07-06 | — | — | WO | claimed |