Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 8/20 | 0.48 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.32 |
| ▸ | GHSR | Q92847 | 1/20 | 0.31 |
| ▸ | PNMT | P11086 | 1/20 | 0.30 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6239385 | 0.74 | PTGS2 (0.60) | PTGS2PTGS1 | |
| SCHEMBL6239381 | 0.72 | PTGS2 (0.60) | PTGS2PTGS1 | |
| SCHEMBL8993518 | 0.72 | PTGS2 (0.44) | PTGS2PSMB5PTGS1 | |
| SCHEMBL8993514 | 0.71 | PTGS2 (0.52) | PTGS2PNMT | |
| SCHEMBL4432809 | 0.71 | LMNA (0.50) | PTGS2 | |
| SCHEMBL8993599 | 0.71 | PTGS2 (0.49) | PTGS2PNMTPTGS1 | |
| SCHEMBL23361312 | 0.70 | PTGS2 (0.58) | PTGS2PSMB5PNMT | |
| SCHEMBL29826462 | 0.70 | PTGS2 (0.58) | PTGS2PSMB5PNMT | |
| SCHEMBL212244 | 0.69 | PTGS2 (0.66) | PTGS2PTGS1 | |
| SCHEMBL17202468 | 0.68 | PTGS2 (0.46) | PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0724566-A1 | 1,2-DIARYLCYCLOPENTENYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-08-07 | — | — | EP | disclosed |
| WO-1995011883-A1 | 1,2-DIARYLCYCLOPENTENYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1995-05-04 | — | — | WO | disclosed |